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Amtagvi (lifileucel) is an IV infusion used to treat certain melanomas.

Amtagvi is available as a single dose of that contains 7.5 x 109 to 72 x 109 viable cells suspended in a 1 to 4 patient-specific infusion bag.

Amtagvi is a tumor-derived autologous T cell immunotherapy indicated for the treatment of adult patients with unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor with or without a MEK inhibitor.

Amtagvi is a tumor-Infiltrating Lymphocyte (TIL) therapy used in the treatment of advanced melanoma. TIL Therapies involve extracting immune cells called lymphocytes from a patient’s tumor, growing them in a laboratory, and then reinfusing them back into the patient’s body.

Amtagvi is in given in an inpatient hospital setting with an intensive care facility.

Amtagvi is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Amtagvi: Chills, Fever, Fatigue, Fast heartrate, Diarrhea Swelling, Rash, Low blood pressure, Hair loss, Infection, Shortness of breath

Serious side effects are rare with Amtagvi. Contact your healthcare provider immediately if you experience any of the following: Hypersensitivity reactions duriing infusion

There are no drug interactions listed for Amtagvi.

Iovance Biotherapeutics, Inc.

It is not known whether Amtagvi will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.

• Lifileucel