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Ado-Trastuzumab Emtansine is available as a single-dose vial containing 100 mg per vial or 160 mg per vial.

Ado-Trastuzumab Emtansine is used to treat HER2-positive metastatic breast cancer (cancer that has spread) in patients who have previously received other medicines (eg, trastuzumab, taxane medicine) that did not work well or whose cancer has returned during or within 6 months of completing treatment. It is also used as additional treatment in patients with HER2-positive early breast cancer who have cancer left after a taxane medicine and trastuzumab-based treatment.

HER2 protein is produced by some breast tumors. Ado-Trastuzumab Emtansine interferes with the growth of this protein which also prevents tumor growth. The tumor cells will then be destroyed by the body.

Ado-Trastuzumab Emtansine is typically dosed as follows:

• 3.6 mg/kg given as an intravenous infusion every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity, or a total of 14 cycles for patients with EBC. Do not administer Ado-Trastuzumab Emtansine at doses greater than 3.6 mg/kg

Ado-Trastuzumab Emtansine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Ado-Trastuzumab Emtansine:

• Fatigue
• Nausea
• Joint pain
• Muscle pain
• Headache
• Nose bleeds
• Low platelet levels
• Bleeding
• Increased liver enzymes

Serious side effects are rare with Ado-Trastuzumab Emtansine. Contact your healthcare provider immediately if you experience any of the following.

• Worsening breathing
• Severe bleeding
• Nerve problems

• No formal drug-drug interaction studies with Ado-Trastuzumab Emtansine have been conducted. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

Ado-Trastuzumab Emtansine can cause embryo-fetal harm when administered during pregnancy. Females of reproductive potential to use effective contraception during treatment with Ado-Trastuzumab Emtansine and for 7 months following the last dose of Ado-Trastuzumab Emtansine.

• Kadcyla