Key facts about Kadcyla
What is Kadcyla?
Kadcyla is the brand name for ado-trastuzumab emtansine IV infusion.
What dosages is Kadcyla available in?
Kadcyla is available as a single-dose vial containing 100 mg per vial or 160 mg per vial.
What is Kadcyla used for?
Kadcyla is used to treat HER2-positive metastatic breast cancer (cancer that has spread) in patients who have previously received other medicines (eg, trastuzumab, taxane medicine) that did not work well or whose cancer has returned during or within 6 months of completing treatment. It is also used as additional treatment in patients with HER2-positive early breast cancer who have cancer left after a taxane medicine and trastuzumab-based treatment.
How does Kadcyla work?
HER2 protein is produced by some breast tumors. Kadcyla interferes with the growth of this protein which also prevents tumor growth. The tumor cells will then be destroyed by the body.
How do I take Kadcyla?
Kadcyla is typically dosed as follows:
- 3.6 mg/kg given as an intravenous infusion every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity, or a total of 14 cycles for patients with EBC. Do not administer Kadcyla at doses greater than 3.6 mg/kg
Is it safe for me to take Kadcyla?
Kadcyla is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Kadcyla Common Side Effects
Common side effects of Kadcyla:
- Fatigue
- Nausea
- Joint pain
- Muscle pain
- Headache
- Nose bleeds
- Low platelet levels
- Bleeding
- Increased liver enzymes
Kadcyla Serious Side Effects
Serious side effects are rare with Kadcyla. Contact your healthcare provider immediately if you experience any of the following.
- Worsening breathing
- Severe bleeding
- Nerve problems
Effects of other drugs, drug classes and over-the-counter products on Kadcyla
- No formal drug-drug interaction studies with Kadcyla have been conducted. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes Kadcyla?
Genentech, Inc.
Is Kadcyla safe in pregnancy?
Kadcyla can cause embryo-fetal harm when administered during pregnancy. Females of reproductive potential to use effective contraception during treatment with Kadcyla and for 7 months following the last dose of Kadcyla.
