ZYPREXA
Used for Schizophrenia
NowPatient helps you obtain your ZYPREXA prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Eli Lilly & Company
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ZYPREXA key facts
What is ZYPREXA?
ZYPREXA is the brand name for olanzapine and is available as an oral tablet and an orally disintegrating tablet.
What dosages is ZYPREXA available in?
ZYPREXA is available as a 5 mg, 10 mg, 15 mg, and 20 mg orally disintegrating tablet and a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg.
What is ZYPREXA used for?
ZYPREXA is an atypical antipsychotic that is used to treat:
- Schizophrenia in adults and children age 13 years and older
- Bipolar I disorder in adults and children age 13 years and older
When taken with fluoxetine (Prozac):
- Bipolar depression in adults and children age 10 years and older
- Depression that haven’t responded well to other treatments
How does ZYPREXA work?
ZYPREXA is an atypical antipsychotic. It’s not completely known how ZYPREXA works, but it’s thought to work by balancing out the levels of chemicals (dopamine and serotonin) in your brain to help control your thoughts, mood, and behaviors.
How do I take ZYPREXA?
ZYPREXA is dosed as follows:
- Schizophrenia
- Adults: The typical starting dose is 5 mg to 10 mg by mouth once daily. The typical maintenance dose is 10 mg to 15 mg once daily
- Children (13 to 17 years old): The typical starting dose is 2.5 mg to 5 mg by mouth once daily. The typical maintenance dose is 10 mg once daily
Bipolar I disorder (mixed or manic episodes):
- Adults: The typical starting dose is 10 mg or 15 mg once daily. The typical maintenance dose ranges from 5 mg to 20 mg once daily. Your dose might be different if your provider is also prescribing lithium (Lithobid) or valproic acid
- Children (13 to 17 years old): The typical starting dose is 2.5 mg to 5 mg by mouth once daily. The typical maintenance dose ranges from 10 mg to 20 mg once daily
Depressive episodes of bipolar I disorder (with fluoxetine (Prozac)):
- Adults: The typical starting dose is 5 mg by mouth once daily in the evening). The typical recommended dose ranges from 5 mg to 12.5 mg
- Children (10 to 17 years old): The typical starting dose is 2.5 mg by mouth once daily
Depression:
- Adults: The typical starting dose is 5 mg by mouth once daily. The typical maintenance dose ranges from 5 mg to 20 mg once daily
Is it safe for me to take ZYPREXA?
ZYPREXA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of these apply to you:
- None with ZYPREXA monotherapy
- When using ZYPREXA and fluoxetine in combination, also refer to the Contraindications section of the package insert for Symbyax
- When using ZYPREXA in combination with lithium or valproate, refer to the Contraindications section of the package inserts for those products
ZYPREXA Common Side Effects
Common side effects of ZYPREXA:
- Sleepiness
- Trouble sleeping
- Accidental injury
- Dizziness
- Weakness
- Dry mouth
- Constipation
- Upset stomach
- Runny nose
ZYPREXA Serious Side Effects
Serious side effects are rare with ZYPREXA. Contact your healthcare provider immediately if you experience any of the following.
- Seizures
- Suicidal thoughts or actions
- Neuroleptic malignant syndrome: fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
- Difficulty swallowing
- Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
- Serious infections: fever, headache, chills, body aches, cough, weakness
- Serious allergic and skin reactions: hives, blisters, skin reddening or peeling, swelling of the lips or tongue, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on ZYPREXA
The following medications may interact with ZYPREXA:
- Diazepam: May potentiate orthostatic hypotension
- Alcohol: May potentiate orthostatic hypotension
- Carbamazepine: Increased clearance of olanzapine
- Fluvoxamine: May increase olanzapine levels
- ZYPREXA and Fluoxetine in Combination: Also refer to the Drug
- Interactions section of the package insert for Symbyax.
- CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs and alcohol
- Antihypertensive Agents: Enhanced antihypertensive effect
- Levodopa and Dopamine Agonists: May antagonize
- levodopa/dopamine agonists
- Lorazepam (IM): Increased somnolence with IM olanzapine
- Other Concomitant Drug Therapy: When using olanzapine in combination with lithium or valproate, refer to the Drug
- Interactions sections of the package insert for those products
Who makes ZYPREXA?
Eli Lilly & Company
Is ZYPREXA safe in pregnancy?
Neonates exposed to antipsychotic drugs, including ZYPREXA, during the third trimester are at risk for
extrapyramidal and/or withdrawal symptoms following delivery. ZYPREXA should be used during
pregnancy only if the potential benefit justifies the potential risk to the fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to atypical
antipsychotics, including ZYPREXA, during pregnancy. Healthcare providers are encouraged to register patients by
contacting the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or visit women’s health
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ZYPREXA prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ZYPREXA prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ZYPREXA savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ZYPREXA savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ZYPREXA | Canadian Prescription Savings* for ZYPREXA | ZYPREXA Drug Coupon* | ZYPREXA Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ZYPREXA?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ZYPREXA | Canadian Prescription Savings* for ZYPREXA | ZYPREXA Drug Coupon* | ZYPREXA Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ZYPREXA savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ZYPREXA drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ZYPREXA, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ZYPREXA prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ZYPREXA is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ZYPREXA for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ZYPREXA prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ZYPREXA prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ZYPREXA
If you are having trouble paying for your ZYPREXA medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZYPREXA you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ZYPREXA is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ZYPREXA
- If ZYPREXA is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ZYPREXA
If you are having trouble paying for your ZYPREXA medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZYPREXA you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ZYPREXA
- If ZYPREXA is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ZYPREXA
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZYPREXA treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZYPREXA you will need to meet the following criteria:
- You must be currently insured and have coverage for ZYPREXA
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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