Key facts about Zolinza
What is Zolinza?
Zolinza is the brand name for vorinostat and is available as an oral capsule.
What dosages is Zolinza available in?
Zolinza is available as a 100 mg oral capsule.
What is Zolinza used for?
Zolinza is a histone deacetylase (HDAC) inhibitor indicated for the treatment of cutaneous manifestations in patients with cutaneous Tcell lymphoma (CTCL) who have progressive, persistent or recurrent disease on or following two systemic therapies.
How does Zolinza work?
Zolinza is a histone deacetylase (HDAC) inhibitor that treats lymphoma.
How do I take Zolinza?
Zolinza is typically taken as 400 mg orally once daily with food. If patient is intolerant to therapy, reduce the dose to 300 mg orally once daily with food. If necessary, reduce the dose further to300 mg once daily with food for 5 consecutive days each week. Reduce dose in patients with mild or moderate hepatic impairment.
Is it safe for me to take Zolinza?
Zolinza is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Zolinza Common Side Effects
Common side effects of Zolinza:
- Diarrhea
- Fatigue
- Nausea
- Thrombocytopenia
- Anorexia
- Foul or metallic taste
Zolinza Serious Side Effects
Serious side effects are rare with Zolinza.
Effects of other drugs, drug classes and over-the-counter products on Zolinza
The following medications may interact with Zolinza:
- Coumarin-derivative anticoagulants: Prolongation of prothrombin time and International Normalized Ratio (INR) have been observed with concomitant use. Monitor INR frequently
Who makes Zolinza?
Merck & Co., Inc.
Is Zolinza safe in pregnancy?
ZOLINZABased on its mechanism of action and findings from animal studies, Zolinza can cause fetal harm
when administered to a pregnant woman. Females should have pregnancy testing done within 7 days prior to initiating therapy
with Zolinza. Females should use effective contraception during treatment with Zolinza and for at least 6 months after the last dose. Males with female partners of reproductive potential to use effective contraception and to avoid
fathering a child during treatment with Zolinza and for at least 3 months after the last dose.
