Used for Cancer

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Updated on 26 Apr 2024

ZIRABEV Uses, Side Effects, Interactions, Warnings & Dosing

What is ZIRABEV?

What is ZIRABEV?

ZIRABEV is the brand name for bevacizumab-bvzr and is available as an injection for IV use.

What dosages is ZIRABEV available in?

What dosages is ZIRABEV available in?

ZIRABEV is available as an injection that contains 100 mg/4 mL (25 mg/mL) or 400 mg/16 mL (25 mg/mL) in a single-dose vial.

What is ZIRABEV used for?

What is ZIRABEV used for?

ZIRABEV is a vascular endothelial growth factor (VEGF) inhibitor that is used to treat:

  • Metastatic, recurrent, or persistent cervical cancer
  • Metastatic colorectal cancer
  • Recurrent glioblastoma
  • Non-squamous non-small cell lung cancer
  • Ovarian, fallopian tube, or primary peritoneal cancer
  • Metastatic renal cell carcinoma
How does ZIRABEV work?

How does ZIRABEV work?

ZIRABEV is a targeted therapy anticancer medication known as a vascular endothelial growth factor (VEGF) inhibitor. VEGF is a specific protein that helps cancer cells grow by promoting and expanding their blood supply. It works by blocking VEGF. This cuts off cancer’s blood supply, helping slow down its growth.

How do I take ZIRABEV?

How do I take ZIRABEV?

ZIRABEV is infused into the veins (IV) by a healthcare provider. Your provider will determine the right dose based on your body weight. The typical dose of ZIRABEV ranges from 5 mg/kg to 15 mg/kg infused IV once every 2 to 3 weeks. Your exact dose and how often you’ll get the infusion also depends on the type of cancer you have and what other anticancer medications your provider prescribes.

Is it safe for me to take ZIRABEV?

Is it safe for me to take ZIRABEV?

ZIRABEV is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

ZIRABEV Common Side Effects

ZIRABEV Common Side Effects

Common side effects of ZIRABEV:

  • Nose bleeds
  • Headache
  • High blood pressure
  • Runny nose
  • Higher levels of protein in urine test
  • Changes in taste
  • Dry skin
  • Bleeding that’s difficult to stop
  • Dry eyes or watery eyes
  • Back pain
  • Peeling or blistering skin
ZIRABEV Serious Side Effects

ZIRABEV Serious Side Effects

Serious side effects are rare with ZIRABEV. Contact your healthcare provider immediately if you experience any of the following.

  • Tears in the gut: fever, chills, intense stomach pain or cramps, bloating
  • Fistulas: skin irritation around the anus, discharge from the anus, swelling or redness around the anus, blood in the stool
  • Serious bleeding (general): unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or stool
  • Bleeding in the lungs: Chest pain, cough, trouble breathing, wheezing, fast heartbeat
  • Stomach bleeds: tiredness, vomiting blood, stomach cramps, black or tarry stool, blood in the stool
  • Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
  • Blood clot in the lungs: cough, chest pain, trouble breathing, racing heart
  • Blood clot in the heart: chest pain, stomach discomfort, sweating, nausea, dizziness
  • Blood clot in the leg: leg cramp, swelling, pain, muscle tightness
  • Dangerously high blood pressure: anxiety, blurry vision, confusion, chest pain, nausea, vomiting, headache
  • Serious kidney problems: trouble thinking clearly, nausea, vomiting, feeling very tired, urinating less than usual
  • Serious infusion reactions: trouble breathing, itching or hives, flushing, swelling, chest pain, fast heartbeat, dizziness, fainting
Effects of other drugs, drug classes and over-the-counter products on ZIRABEV

Effects of other drugs, drug classes and over-the-counter products on ZIRABEV

There are no major drug interactions listed for ZIRABEV. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Who makes ZIRABEV?

Who makes ZIRABEV?


Is ZIRABEV safe in pregnancy?

Is ZIRABEV safe in pregnancy?

ZIRABEV may cause fetal harm when administered to a pregnant woman. If you can become pregnant, use effective contraception during treatment with ZIRABEV and for 6 months after the last dose.


What to do if you missed your ZIRABEV dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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