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Zilucoplan is available as 16.6 mg/0.416 mL, 23 mg/0.574 mL, or 32.4 mg/0.81 mL of Zilucoplan in single-dose prefilled syringes.

Zilucoplan is a complement inhibitor indicated for the treatment of generalized myasthenia gravis (gMG) in adult patients with anti-AChR antibodies.

Zilucoplan is a complement inhibitor. The exact way that the medication works isn’t clear, but it’s thought to prevent breakdown of complement proteins. These complement proteins, which are part of the immune system, are activated by harmful antibodies (anti-Ach antibodies) to disrupt communication between nerves and muscles. By blocking these proteins, Zilucoplan helps to ease gMG symptoms and improve the ability to perform daily living, like walking or speaking.

Your Zilucoplan dose depends on your body weight.

Adults weighing less than 123 lbs (56 kg):

• The typical dose is 16.6 mg injected under the skin once daily.
• Adults weighing between 123 to 168 lbs (56-76 kg): The typical dose is 23 mg injected under the skin once daily.
• Adults weighing 169 lbs (77 kg) and more: The typical dose is 32.4 mg injected under the skin once daily.

Zilucoplan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Patients with unresolved serious Neisseria meningitidis infection

Common side effects of Zilucoplan:

• Injection site reactions
• Upper respiratory tract infections
• Diarrhea
• Urinary tract infection
• Nausea or vomiting

Serious side effects are rare with Zilucoplan. Contact your healthcare provider immediately if you experience any of the following:

• Meningococcal infections: headache, stiff neck or back, muscle ache, nausea, vomiting, fever, flu-like symptoms, sensitivity to bright light, confusion, rash
• Pancreatitis: stomach pain that won’t go away, pain radiating to the back, nausea, or vomiting

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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