ZEPOSIA
NowPatient helps you obtain your ZEPOSIA prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Bristol-Myers Squibb
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ZEPOSIA key facts
What is ZEPOSIA?
ZEPOSIA is the brand name for ozanimod and is available as an oral capsule.
What dosages is ZEPOSIA available in?
ZEPOSIA is available as a 0.23 mg, 0.46 mg, 0.92 mg oral capsule.
What is ZEPOSIA used for?
ZEPOSIA is a sphingosine 1-phosphate (S1P) receptor modulator that is used to treat:
- Relapsing forms of multiple sclerosis (MS) in adults
- Moderate-to-severe ulcerative colitis (UC) in adults
How does ZEPOSIA work?
ZEPOSIA is a sphingosine 1-phosphate (S1P) receptor modulator. It attaches to the S1P receptor protein that’s found on your white blood cells. It’s thought that this blocks white blood cells from leaving your lymph nodes and releasing into the body. This helps to lower inflammation in the body, which might help improve symptoms of UC and MS.
How do I take ZEPOSIA?
ZEPOSIA is typically dosed as follows:
- Days 1 to 4: The typical dose is 0.23 mg by mouth once daily
- Days 5 to 7: The typical dose is 0.46 mg by mouth once daily
- Day 8 and onward: The typical dose is 0.92 mg by mouth once daily
Your provider will adjust the dose if you have liver problems
Is it safe for me to take ZEPOSIA?
ZEPOSIA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:
- In the last 6 months, experienced myocardial infarction, unstable angina, stroke, transient ischemic attack, decompensated heart failure requiring hospitalization, or Class III or IV heart failure
- Presence of Mobitz type II second-degree or third degree atrioventricular (AV) block, sick sinus syndrome, or sino-atrial block, unless the patient has a functioning
pacemaker - Severe untreated sleep apnea
- Concomitant use of a monoamine oxidase inhibitor
ZEPOSIA Common Side Effects
Common side effects of ZEPOSIA:
- Upper respiratory infection
- High liver enzyme tests
- Stomach pain
- Back pain
- Sudden low blood pressure when standing
ZEPOSIA Serious Side Effects
Serious side effects are rare with ZEPOSIA. Contact your healthcare provider immediately if you experience any of the following.
- Serious infection: fever, chills, sweating, weakness, trouble breathing, cough, diarrhea, stomach pain, painful urination
- Serious brain infection (PML): weakness on one side of the body, clumsiness, confusion, changes in personality, changes in vision, headache, stiff neck, light sensitivity, fever, seizures
- Dangerously slow heart rate: tiredness, weakness, confusion, feeling faint, trouble breathing, chest pain
Severely high blood pressure: severe headaches, nosebleeds, trouble breathing, vision changes, irregular heartbeat, chest pain - Serious liver problems: nausea, vomiting, stomach pain, swelling of your stomach, yellowing of your skin or the whites of your eyes, clay-colored stool, confusion
Posterior reversible encephalopathy syndrome (PRES): seizures; sudden, severe headaches; sudden changes in vision; sudden confusion
Effects of other drugs, drug classes and over-the-counter products on ZEPOSIA
The following medications may interact with ZEPOSIA:
- Vaccination: Avoid use of live attenuated vaccines during and for up to 3 months after treatment with ZEPOSIA
- Co-administration of ZEPOSIA with drugs or over-the-counter medications that can increase norepinephrine or serotonin (e.g., opioid drugs, SSRIs
- SNRIs, tricyclics, tyramine) is not recommended Monitor patients for hypertension with concomitant use.
- Co-administration of ZEPOSIA with strong CYP2C8 inducers (e.g. rifampin) reduces the exposure of the major active metabolites of ozanimod, which may decrease the efficacy of ZEPOSIA and should be avoided.
- Co-administration of ZEPOSIA with MAO inhibitors (e.g., selegiline phenelzine, linezolid) is contraindicated. At least 14 days should elapse between discontinuation of ZEPOSIA and initiation of treatment with MAO inhibitors
- Co-administration of ZEPOSIA with strong CYP2C8 inhibitors (e.g., gemfibrozil) is not recommended
Who makes ZEPOSIA?
Bristol-Myers Squibb
Is ZEPOSIA safe in pregnancy?
ZEPOSIA may harm your unborn baby. Talk with your healthcare provider if you are pregnant or plan to become pregnant. If you are a female who can become pregnant, you should use effective birth control during your treatment with ZEPOSIA and for 3 months after you stop taking ZEPOSIA. Talk with your healthcare provider about what birth control method is right for you during this time. Tell your healthcare provider right away if you become pregnant while taking ZEPOSIA or if you become pregnant within 3 months after you stop taking ZEPOSIA.Pregnancy Registry for MS patients: There is a pregnancy registry for women with multiple sclerosis who become pregnant during treatment with ZEPOSIA. If you become pregnant while taking ZEPOSIA, tell your healthcare provider right away. Talk to your healthcare provider about registering with the ZEPOSIA Pregnancy Registry. The purpose of this registry is to collect information about your health and your baby’s health. Either you or your healthcare provider can enroll you in this registry by calling 1-877-301-9314 or visiting Zeposia MS pregnancy registry
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ZEPOSIA prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ZEPOSIA prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ZEPOSIA savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ZEPOSIA savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ZEPOSIA | Canadian Prescription Savings* for ZEPOSIA | ZEPOSIA Drug Coupon* | ZEPOSIA Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ZEPOSIA?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ZEPOSIA | Canadian Prescription Savings* for ZEPOSIA | ZEPOSIA Drug Coupon* | ZEPOSIA Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ZEPOSIA savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ZEPOSIA drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ZEPOSIA, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ZEPOSIA prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ZEPOSIA is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ZEPOSIA for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ZEPOSIA prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ZEPOSIA prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ZEPOSIA
If you are having trouble paying for your ZEPOSIA medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZEPOSIA you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ZEPOSIA is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ZEPOSIA
- If ZEPOSIA is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ZEPOSIA
If you are having trouble paying for your ZEPOSIA medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZEPOSIA you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ZEPOSIA
- If ZEPOSIA is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ZEPOSIA
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZEPOSIA treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZEPOSIA you will need to meet the following criteria:
- You must be currently insured and have coverage for ZEPOSIA
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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