Save on Xigduo XR with Coupons, Discounts & Savings Programs

Xigduo XR is the brand name for dapagliflozin and metformin HCl and is available as an extended-release tablet.

Xigduo XR is available as an extended-release tablet in one of the following combinations:

• 2.5 mg dapagliflozin/1000 mg metformin HCl
• 5 mg dapagliflozin/500 mg metformin HCl
• 5 mg dapagliflozin/1000 mg metformin HCl
• 10 mg dapagliflozin/500 mg metformin HCl
• 10 mg dapagliflozin/1000 mg metformin HCl

Xigduo XR is a SGLT2 inhibitor/biguanide that is used to treat type 2 diabetes.

Xigduo XR is a combination of two medications.

• Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent the absorption of sugar and sodium (salt) back into your body. For Type 2 diabetes, it lowers blood sugar by causing your body to get rid of excess sugar through your urine. For heart failure and CKD, it improves blood flow and oxygen delivery to the heart and kidneys
• Metformin is a biguanide that lowers blood sugar in several ways. It lowers the amount of sugar that your liver makes. It also makes your body more sensitive to the effects of insulin. When your body is able to use insulin better, it can move more blood sugar into your cells to use as energy. In addition, metformin lowers the amount of sugar that gets absorbed through your intestines. As a result, metformin helps lower the amount of sugar in your bloodstream

Your provider will help determine your starting dose of Xigduo XR based on the doses of your current diabetes medications. If you’re not already taking dapagliflozin, the typical starting dose of dapagliflozin is 5 mg by mouth once daily. If you have heart failure or kidney problems, the typical recommended dose of dapagliflozin is 10 mg once daily. The maximum dose of Xigduo XR is 10 mg/2000 mg (dapagliflozin/metformin) by mouth once daily.

Xigduo XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Moderate to severe renal impairment: (eGFR below 60 mL/min/1.73 m2), end-stage renal disease or dialysis.
  History of serious hypersensitivity to dapagliflozin or hypersensitivity to metformin hydrochloride
• Metabolic acidosis, including diabetic ketoacidosis

Common side effects of Xigduo XR:

• Redness, itching, and other symptoms of a genital yeast infection
• Pain or discomfort while urinating and other symptoms of an urinary tract infection
• Sore throat, stuffy nose, and other symptoms of the common cold
• Diarrhea
• Headache

Serious side effects are rare with Xigduo XR. Contact your healthcare provider immediately if you experience any of the following.

• Too much lactic acid: confusion, feeling weak, fast or slow heartbeat, rapid breathing, no appetite, nausea, vomiting, stomach pain
• High ketone levels in the blood: trouble breathing, vomiting, belly pain, dry skin and mouth, feeling very tired, fruity-smelling breath
• Serious kidney problems: confusion, weakness, tiredness, urinating less than usual
• Dehydration (dangerously low body fluids): dizziness, lightheadedness, confusion, dark-colored urine
• Serious genital infection: pain, swelling, or redness in the genital area, fever, weakness

The following medications may interact with Xigduo XR:

• Carbonic anhydrase inhibitors may increase the risk of lactic acidosis
• Consider more frequent monitoring
• Drugs that reduce metformin clearance (such as ranolazine, vandetanib dolutegravir, and cimetidine) may increase the accumulation of metformin. Consider the benefits and risks of concomitant use
• Alcohol can potentiate the effect of metformin on lactate metabolism
• Warn patients against excessive alcohol intake

AstraZeneca

Xigduo XR may harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your healthcare provider about the best way to control your blood sugar.

• Dapagliflozin/Metformin Hydrochloride Extended-Release