XIGDUO XR
Used for Type 2 Diabetes
Are you tired of high medication costs? Our service offers unbeatable savings on your XIGDUO XR prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by AstraZeneca
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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XIGDUO XR key facts
What is XIGDUO XR?
XIGDUO XR is the brand name for dapagliflozin and metformin HCl and is available as an extended-release tablet.
What dosages is XIGDUO XR available in?
XIGDUO XR is available as an extended-release tablet in one of the following combinations:
- 2.5 mg dapagliflozin/1000 mg metformin HCl
- 5 mg dapagliflozin/500 mg metformin HCl
- 5 mg dapagliflozin/1000 mg metformin HCl
- 10 mg dapagliflozin/500 mg metformin HCl
- 10 mg dapagliflozin/1000 mg metformin HCl
What is XIGDUO XR used for?
XIGDUO XR is a SGLT2 inhibitor/biguanide that is used to treat type 2 diabetes.
How does XIGDUO XR work?
XIGDUO XR is a combination of two medications.
- Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent the absorption of sugar and sodium (salt) back into your body. For Type 2 diabetes, it lowers blood sugar by causing your body to get rid of excess sugar through your urine. For heart failure and CKD, it improves blood flow and oxygen delivery to the heart and kidneys
- Metformin is a biguanide that lowers blood sugar in several ways. It lowers the amount of sugar that your liver makes. It also makes your body more sensitive to the effects of insulin. When your body is able to use insulin better, it can move more blood sugar into your cells to use as energy. In addition, metformin lowers the amount of sugar that gets absorbed through your intestines. As a result, metformin helps lower the amount of sugar in your bloodstream
How do I take XIGDUO XR?
Your provider will help determine your starting dose of XIGDUO XR based on the doses of your current diabetes medications. If you’re not already taking dapagliflozin, the typical starting dose of dapagliflozin is 5 mg by mouth once daily. If you have heart failure or kidney problems, the typical recommended dose of dapagliflozin is 10 mg once daily. The maximum dose of XIGDUO XR is 10 mg/2000 mg (dapagliflozin/metformin) by mouth once daily.
Is it safe for me to take XIGDUO XR?
XIGDUO XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Moderate to severe renal impairment: (eGFR below 60 mL/min/1.73 m2), end-stage renal disease or dialysis.
History of serious hypersensitivity to dapagliflozin or hypersensitivity to metformin hydrochloride - Metabolic acidosis, including diabetic ketoacidosis
XIGDUO XR Common Side Effects
Common side effects of XIGDUO XR:
- Redness, itching, and other symptoms of a genital yeast infection
- Pain or discomfort while urinating and other symptoms of an urinary tract infection
- Sore throat, stuffy nose, and other symptoms of the common cold
- Diarrhea
- Headache
XIGDUO XR Serious Side Effects
Serious side effects are rare with XIGDUO XR. Contact your healthcare provider immediately if you experience any of the following.
- Too much lactic acid: confusion, feeling weak, fast or slow heartbeat, rapid breathing, no appetite, nausea, vomiting, stomach pain
- High ketone levels in the blood: trouble breathing, vomiting, belly pain, dry skin and mouth, feeling very tired, fruity-smelling breath
- Serious kidney problems: confusion, weakness, tiredness, urinating less than usual
- Dehydration (dangerously low body fluids): dizziness, lightheadedness, confusion, dark-colored urine
- Serious genital infection: pain, swelling, or redness in the genital area, fever, weakness
Effects of other drugs, drug classes and over-the-counter products on XIGDUO XR
The following medications may interact with XIGDUO XR:
- Carbonic anhydrase inhibitors may increase the risk of lactic acidosis
- Consider more frequent monitoring
- Drugs that reduce metformin clearance (such as ranolazine, vandetanib dolutegravir, and cimetidine) may increase the accumulation of metformin. Consider the benefits and risks of concomitant use
- Alcohol can potentiate the effect of metformin on lactate metabolism
- Warn patients against excessive alcohol intake
Who makes XIGDUO XR?
AstraZeneca
Is XIGDUO XR safe in pregnancy?
XIGDUO XR may harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your healthcare provider about the best way to control your blood sugar.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my XIGDUO XR prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your XIGDUO XR prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient XIGDUO XR savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient XIGDUO XR savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for XIGDUO XR | Canadian Prescription Savings* for XIGDUO XR | XIGDUO XR Drug Coupon* | XIGDUO XR Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of XIGDUO XR?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for XIGDUO XR | Canadian Prescription Savings* for XIGDUO XR | XIGDUO XR Drug Coupon* | XIGDUO XR Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the XIGDUO XR savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the XIGDUO XR drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for XIGDUO XR, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the XIGDUO XR prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, XIGDUO XR is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed XIGDUO XR for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the XIGDUO XR prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the XIGDUO XR prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for XIGDUO XR
If you are having trouble paying for your XIGDUO XR medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for XIGDUO XR you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- XIGDUO XR is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers XIGDUO XR
- If XIGDUO XR is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for XIGDUO XR
If you are having trouble paying for your XIGDUO XR medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for XIGDUO XR you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers XIGDUO XR
- If XIGDUO XR is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for XIGDUO XR
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your XIGDUO XR treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for XIGDUO XR you will need to meet the following criteria:
- You must be currently insured and have coverage for XIGDUO XR
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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