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Winrevair is the brand name for sotatercept-csrk and is available as a subcutaneous injection.

Winrevair is available as a 45 mg or 60 mg single-dose vial.

Winrevair is an FDA-approved medication used to treat adults with pulmonary arterial hypertension (PAH).

Winrevair is an activin signaling inhibitor, which means it blocks the activity of activin in the body. By balancing signals for blood vessel growth, Winrevair prevents the blood vessels in the lungs from getting too thick.

Your dose of Winrevair will be based on your weight in kilograms (kg). The first dose is typically 0.3 mg/kg injected under the skin. Three weeks after that, the typical dose is 0.7 mg/kg injected under the skin every 3 weeks as a maintenance dose.

Winrevair is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Winrevair:

• Headache
• Nose bleeds
• Rash
• Spider veins
• Diarrhea
• Dizziness
• Skin redness

Serious side effects are rare with Winrevair. Contact your healthcare provider immediately if you experience any of the following:

• Signs or symptoms of a blood clot: redness or swelling of the legs, chest pain, difficulty breathing, weakness of the face, sudden confusion
• Severe bleeding: blood in the urine, stool that appears black and sticky, vomit that looks like coffee grounds, bruises that keep getting bigger

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Merck & Co., Inc.

If you can get pregnant, make sure to use effective birth control while you’re taking Winrevair and for at least 4 months after your last dose. This medication can be harmful to an unborn baby.

• Sotatercept-Csrk