VITRAKVI
Used for Cancer
NowPatient can significantly lower the cost* of your prescription medication by providing free access to drug coupons, savings cards, patient assistance programs and other out of pocket discount programs. Whether you’re insured, uninsured, or underinsured, we empower you with transparency and cost-saving tools to make your VITRAKVI more affordable.
Manufactured by Bayer Healthcare
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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VITRAKVI key facts
What is VITRAKVI?
VITRAKVI is the brand name for larotrectinib oral capsules and solution.
What dosages is VITRAKVI available in?
VITRAKVI is available as a 25 mg and 100 mg oral capsule and a 20 mg/mL oral solution.
What is VITRAKVI used for?
VITRAKVI is a kinase inhibitor indicated for the treatment of adult andpediatric patients with solid tumors that:
- Have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation,
- Are metastatic or where surgical resection is likely to result in severe morbidity
- Have no satisfactory alternative treatments or that have progressed following treatment
How does VITRAKVI work?
VITRAKVI works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
How do I take VITRAKVI?
VITRAKVI is dosed as follows:
- Recommended Dosage in Adult and Pediatric Patients with Body Surface
- Area of 1 Meter-Squared or greater: 100 mg orally twice daily
- Recommended Dosage in Pediatric Patients with Body Surface Area of Less Than 1 Meter-Squared: 100 mg/m2 orally twice daily
Is it safe for me to take VITRAKVI?
VITRAKVI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
VITRAKVI Common Side Effects
Common side effects of VITRAKVI:
- Cough
- Leukopenia
- Constipation
- Diarrhea
- Dizziness
- Hypocalcemia
- Nausea
- Vomiting
- Fever
- Abdominal pain
VITRAKVI Serious Side Effects
Serious side effects are rare with VITRAKVI. Contact your doctor if you experience any of the following.
- Central nervous system (CNS) problems: dizziness, confusion, problems with concentration, attention, and memory, changes in your mood, and sleep
problems - Bone fractures: pain, changes in your ability to move around, or bone abnormalities
- Liver problems: yellowing of your skin or the white part of your eyes (jaundice), dark or brown urine, bruising or bleeding more easily than normal, tiredness, pain in the upper right side of your stomach area (abdomen), nausea or vomiting
Effects of other drugs, drug classes and over-the-counter products on VITRAKVI
- The following medications may interact with VITRAKVI:
- Strong CYP3A4 Inhibitors: Avoid coadministration of strong CYP3A4 inhibitors with VITRAKVI. If coadministration cannot be avoided, reduce the VITRAKVI dose.
- Moderate CYP3A4 Inhibitors: Monitor for adverse reactions more frequently in patients coadministered a moderate CYP3A4 inhibitor with VITRAKVI and reduce the VITRAKVI dosage based on severity of adverse reactions
- Strong CYP3A4 Inducers: Avoid coadministration of strong CYP3A4 inducers with VITRAKVI. If coadministration cannot be avoided, increase
- the VITRAKVI dose
- Moderate CYP3A4 Inducers: Increase the VITRAKVI dose
- Sensitive CYP3A4 Substrates: Avoid coadministration of sensitive CYP3A4 substrates with VITRAKVI
Who makes VITRAKVI?
Bayer Healthcare
Is VITRAKVI safe in pregnancy?
VITRAKVI can harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with VITRAKVI or think you may be pregnant.
If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with VITRAKVI. Females who are able to become pregnant should use effective birth control (contraception) during treatment and for 1 week after the last dose of VITRAKVI. Talk
to your healthcare provider about birth control methods that may be right for you. Males with female partners who are able to become pregnant should use effective birth control during treatment with VITRAKVI and for 1 week after the last dose of
VITRAKVI. VITRAKVI may affect fertility in females and may affect your ability to become pregnant.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my VITRAKVI prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your VITRAKVI prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient VITRAKVI savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient VITRAKVI savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for VITRAKVI | Canadian Prescription Savings* for VITRAKVI | VITRAKVI Drug Coupon* | VITRAKVI Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of VITRAKVI?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for VITRAKVI | Canadian Prescription Savings* for VITRAKVI | VITRAKVI Drug Coupon* | VITRAKVI Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the VITRAKVI savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the VITRAKVI drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for VITRAKVI, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the VITRAKVI prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, VITRAKVI is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed VITRAKVI for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the VITRAKVI prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the VITRAKVI prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for VITRAKVI
If you are having trouble paying for your VITRAKVI medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for VITRAKVI you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- VITRAKVI is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers VITRAKVI
- If VITRAKVI is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for VITRAKVI
If you are having trouble paying for your VITRAKVI medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for VITRAKVI you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers VITRAKVI
- If VITRAKVI is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for VITRAKVI
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your VITRAKVI treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for VITRAKVI you will need to meet the following criteria:
- You must be currently insured and have coverage for VITRAKVI
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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