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Valbenazine is available as a 40 mg, 60 mg, and 80 mg oral capsule.

Valbenazine is a VMAT2 inhibitor that’s used to treat tardive dyskinesia (TD) and chorea associated with Huntington’s disease in adults.

Valbenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor. It’s not exactly known how the medication helps with movement problems, but it’s thought to block the VMAT2 protein in your brain. This lowers the amount of certain chemicals, like dopamine and serotonin, that are released in the brain and are involved with movements of your body.

The typical starting dose of Valbenazine is 40 mg by mouth once daily, with or without food. Depending on how you tolerate and respond to the medication, the dose may be gradually raised up to the recommended dose of 80 mg once daily.

Valbenazine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known hypersensitivity to Valbenazine or any components of the product

Common side effects of Valbenazine:

• Sleepiness
• Dry mouth
• Constipation
• Blurry vision
• Trouble urinating
• Fatigue
• Hives or rash
• Trouble sleeping
• Diarrhea
• Nausea
• Depression
• Back pain

Serious side effects are rare with Valbenazine. Contact your healthcare provider immediately if you experience any of the following:

• Suicidal thoughts and behaviors
• Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint, lightheaded
• Neuroleptic malignant syndrome: high fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
• Movement abnormalities (parkinsonism): tremor, slow movement, impaired speech, muscle stiffness, losing balance easily
• Serious allergic reaction: hives; rash, swelling of the face, tongue, or around the eyes, trouble breathing; wheezing, trouble swallowing

The following medications may interact with Valbenazine:

• MAOIs
• Strong CYP3A4 inducers or inhibitors
• Strong CYP2D6 inhibitors

Various FDA-approved generic manufacturers

Valbenazine may harm your unborn baby. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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