UrsodiolPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Ursodiol
    Generic for Actigall
    30 capsules $12.9 USD
    Save $177.00
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Do you need a prescription for ursodiol?

Yes, ursodiol is only available with a valid physician Rx.

How much is ursodiol without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase ursodiol, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for ursodiol in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a ursodiol savings card?

Yes. Save up to 90% on your ursodiol with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a ursodiol coupon provider in the US?

No. Now Patient does not provide ursodiol coupons or FREE ursodiol samples.

Do you accept commercial, Medicare or Medicaid coverage for ursodiol in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much ursodiol?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using ursodiol. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much ursodiol. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic ursodiol?

Generic ursodiol refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of ursodiol

Ursodiol is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain liver diseases, including primary biliary cholangitis (PBC) and certain types of gallstones.

Active ingredient of ursodiol

The active ingredient of ursodiol is ursodeoxycholic acid.

US brand name of ursodiol and manufacturer

Ursodiol is available under various brand names in the US, such as Actigall, Reltone, Urso 250, and Urso Forte, and is manufactured by multiple pharmaceutical companies.

UK brand name of ursodiol and manufacturer

In the UK, ursodiol is available under various brand names, and the manufacturers may vary.

Prescription requirement for ursodiol

A prescription (Rx) is required for ursodiol in both the US and the UK.

Availability of ursodiol in the UK with NHS prescription

Ursodiol is available in the UK with an NHS prescription.

Conditions treated by ursodiol

Ursodiol is primarily used to treat primary biliary cholangitis (PBC), formerly known as a primary biliary cirrhosis, a chronic liver disease that affects the bile ducts. It can also be used to dissolve certain types of gallstones in the gallbladder.

Ursodiol’s mechanism of action

Ursodiol works by reducing the production and absorption of cholesterol in the liver, which helps to improve the flow of bile and prevent the buildup of toxic substances. It can also help dissolve cholesterol gallstones by altering the composition of bile and promoting their gradual breakdown.

Forms of ursodiol available

Ursodiol is available in the form of oral capsules or tablets.

Dosage of ursodiol

The dosage of ursodiol may vary depending on the specific condition being treated and individual patient factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for ursodiol use

Ursodiol should be taken exactly as directed by the healthcare provider. The capsules or tablets should be swallowed whole with water and should not be crushed or chewed.

Warnings and precautions for ursodiol

  • Ursodiol should not be used in patients with certain types of gallstones, such as calcified or radiopaque stones
  • Tell your doctor if you have gallbladder or bile duct problems such as acute cholecystitis, biliary obstruction, biliary-gastrointestinal fistula, liver disease (such as ascites, variceal bleeding, or hepatic encephalopathy), cholecystitis or pancreatitis
  • It may take several months of treatment with ursodiol to see the full benefits in the treatment of gallstones
  • You will need regular medical tests, including blood tests to check your liver function

Use of ursodiol during pregnancy

Ursodiol can be used during pregnancy if prescribed by a healthcare provider. The potential risks and benefits should be evaluated for each individual case.

Use of ursodiol while breastfeeding

Ursodiol is excreted into breast milk but is considered compatible with breastfeeding. However, consultation with a healthcare provider is necessary to discuss the specific situation.

Possible side effects of ursodiol

In clinical trials common side effects of ursodiol may include bitter taste, diarrhea, nausea, abdominal pain, back pain, and constipation. In rare cases, allergic reactions or hepatotoxicity (liver toxicity) may occur. Get medical help right away if you have a serious side effect such as an allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, skin rash, blisters, and serious skin reactions.

Interactions with other drugs

Ursodiol may interact with other medications, including antacids containing aluminum. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medications, salt substitutes, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to ursodiol

There are no other drugs that are exactly similar to ursodiol, as it is a specific bile acid medication used for liver and gallstone conditions.


  • FDA Prescribing Information for Ursodiol
  • MHRA product information for Ursodiol
  • NHS UK
  • Drugs.com
  • WebMD

About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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