UROXATRAL

Both medications are nonselective alpha-1 blockers, leading to a reduction in blood pressure. However, selective alpha-blockers like Flomax can also lower blood pressure, albeit to a lesser extent than nonselective ones. Alternative selective alpha-blockers to Flomax include Uroxatral (alfuzosin).

Most α1-adrenoceptor antagonists are designed to affect blood pressure. Sustained-release alfuzosin and tamsulosin have the lowest likelihood of causing side effects. Tamsulosin is user-friendly as it doesn’t require dose titration and can be taken once a day.

Here are some medications with their respective dosage forms and brand names:
Alfuzosin: Oral tablet, extended release (Brand: Uroxatral)
Tamsulosin: Oral capsule (Brand: Flomax)
Finasteride: Oral tablet (Brands: Propecia, Proscar)

In individuals with benign prostatic hyperplasia (BPH), both tam and alfuzosin, used at different times, show similarly favorable outcomes. When one alpha-blocker doesn’t yield the desired effect in BPH treatment, switching to another alpha-blocker can be beneficial.

For more information about Uroxatral oral, a generic drug, the average cost for 30 Tablet Extended Release 24 Hour(s) of 10MG each is $26.81. You can get alfuzosin ER at a discounted price of $15.20 by using the NowPatient Rx Advantage Card, saving 43%.

Clinical studies indicate that people usually start experiencing relief from prostate symptoms after a few days of taking alfuzosin ER (Uroxatral). However, to experience the maximum benefit, it’s typically necessary to take this medication for a month or longer.

To prevent dizziness or fainting, your doctor may recommend taking your initial dose of alfuzosin with food at bedtime to allow your body to adapt to its effects. Consistent use of this medication is crucial for optimal results, so taking it after the same meal each day can help you remember.

Uroxatral (alfuzosin) can lower blood pressure and may cause dizziness or fainting, especially when combined with heart or blood pressure medications. It’s advisable to avoid activities like driving or hazardous tasks until you understand how alfuzosin affects you. If you experience lightheadedness or feel like you might faint, contact your doctor promptly.

Flomax is known to improve bladder emptying with each urination, reducing the frequency of bathroom trips. It effectively alleviates symptoms of benign prostatic hyperplasia (BPH), including difficulties in starting and stopping the urine stream.

Both drugs are effective for their licensed indications. Your doctor will discuss which medication is the most suitable considering your health circumstances and condition which is being treated.

The parasympathetic nervous system controls erection, while the sympathetic nervous system controls ejaculation. Tamsulosin acts as a sympathetic blocker, relaxing specific prostate muscles that may otherwise impede urine flow. Unfortunately, a side effect of this action is a reduction or even prevention of ejaculation.

Studies have shown that alfuzosin not only improves lower urinary tract symptoms (LUTS) but also seems to preserve ejaculatory function (EjD).

In individuals with benign prostatic hyperplasia (BPH), both tam and alfuzosin, used at different times, show similarly favorable outcomes. When one alpha-blocker doesn’t yield the desired effect in BPH treatment, switching to another alpha-blocker can be beneficial.

There is no significant difference in terms of efficacy (passing stones) for the management of distal ureteral stones between both medications. Both alfuzosin and tamsulosin are considered safe and effective. Furthermore, alfuzosin tends to be better tolerated, with fewer side effects than tamsulosin.

Alfuzosin, when taken at a daily dose of 10 mg for one year, has been shown to be effective in improving lower urinary tract symptoms (LUTS) and overall quality of life. Moreover, it may even enhance sexual function in men with concomitant erectile and/or ejaculatory dysfunction.

Clinical studies indicate that people usually start experiencing relief from prostate symptoms after a few days of taking alfuzosin ER (Uroxatral). However, to experience the maximum benefit, it’s typically necessary to take this medication for a month or longer.

Alpha blockers and antimuscarinics are commonly used to manage overactive bladder. Examples include dutasteride (a 5-alpha reductase inhibitor) and tamsulosin (an alpha blocker) or finasteride (a 5-alpha reductase inhibitor) and doxazosin (an alpha blocker).

Using alfuzosin together with tamsulosin is not recommended. Combining these medications may lead to a significant drop in blood pressure and an increase in heart rate, especially when transitioning from a sitting or lying position.

Alfuzosin is licensed by the FDA and is safe and effective for use in treating the licensed indication.

Specifically for BPH treatment, tamsulosin’s medical cost was found to be significantly higher than that of doxazosin and terazosin. However, there was no significant cost difference when comparing tamsulosin with alfuzosin.

If you are taking both medications, you may require a dose adjustment or more frequent blood pressure monitoring. It is crucial to inform your doctor about all the medications you are using, including vitamins and herbs.

Most α1-adrenoceptor antagonists are designed to influence blood pressure, with sustained-release alfuzosin and tamsulosin having the lowest tendency to induce side effects. Tamsulosin is user-friendly as it doesn’t necessitate dose titration and can be taken once daily.

Alfuzosin aids in relaxing the muscles in the prostate and the bladder opening. This relaxation may enhance urine flow and alleviate associated symptoms.

To prevent potential dizziness or fainting, your physician may advise taking your initial alfuzosin dose with a meal at bedtime to allow your body to acclimate to its effects. Consistent medication intake is essential for maximizing benefits. To aid in memory, take it after the same meal daily.

It might even enhance sexual function in men experiencing concurrent erectile and/or ejaculatory dysfunction.

The administration of 10 mg of alfuzosin over two years in real-world practice effectively improves lower urinary tract symptoms (LUTS) and quality of life. It is well-tolerated from a cardiovascular perspective, including among elderly men and those receiving antihypertensive co-medication.

Typically, it is taken once daily, immediately after a meal. Avoid taking alfuzosin on an empty stomach. To ensure regularity, take it after the same meal every day. Adhere to the instructions on your prescription label carefully, and don’t hesitate to ask your doctor or pharmacist for clarification on any part you find unclear.

For individuals with liver issues: If you have moderate or severe liver problems, it is not advisable to take alfuzosin. Impaired liver function may result in a longer presence of the drug in your system, increasing the risk of side effects. For those with kidney problems: Exercise caution when using this medication, particularly if you have severe kidney impairment.

Other medications that may interact with alfuzosin include:
Other alpha-blocker medications such as doxazosin, prazosin, silodosin, tamsulosin, terazosin.
Certain medications for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole.
Cisapride.
Dronedarone.
Droperidol.
Pimozide.
Ritonavir.

In individuals with lower urinary tract symptoms due to benign prostatic hyperplasia (BPH), both alfuzosin and tamsulosin were well-tolerated and demonstrated similar efficacy. Alfuzosin may be preferred for sexually active patients due to fewer reported ejaculatory abnormalities.

No statistically significant differences were found between the alfuzosin and tamsulosin treated groups for AUA score, post-void residual urine volume, and peak flow rate. Both alfuzosin and tamsulosin were well-tolerated.

Since its approval and increased usage, several cases of clinically evident acute liver injury linked to alfuzosin have been documented.

Alfuzosin doesn’t shrink the prostate but acts by relaxing the muscles in the prostate and bladder. This helps alleviate symptoms of BPH, including difficulties in initiating urine flow, a weak stream, and frequent or urgent urination (including nocturia).

Important note for consumers: While taking alfuzosin, avoid consuming grapefruit or grapefruit juice. Grapefruit juice can elevate the blood concentrations of alfuzosin by inhibiting its metabolism in the body, potentially causing a drop in blood pressure.

Alfuzosin may lead to a condition that affects heart rhythm known as QT prolongation. This rare but serious condition can result in fast or irregular heartbeat and other symptoms (e.g., severe dizziness, fainting) requiring immediate medical attention.

Alfuzosin is associated with a low incidence of temporary elevation of serum aminotransferases and rare instances of clinically apparent acute liver injury.

Clinical studies suggest that individuals typically start experiencing relief from prostate symptoms after a few days of taking alfuzosin ER (Uroxatral). However, to experience the maximum benefit, it’s usually necessary to continue this medication for a month or more.

In an unadjusted cohort, the incidence of dementia in the tamsulosin, doxazosin, terazosin, alfuzosin, and no-medication cohorts was 17.97%, 18.55%, 20.64%, 17.62%, and 22.60%, respectively.

Following the oral administration of UROXATRAL 10 mg tablets, the apparent elimination half-life is approximately 10 hours.