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Uplizna is the brand name for inebilizumab-cdon and is available as an intravenous infusion.

Uplizna is available as a 100 mg/10 mL (10 mg/mL) solution in a single-dose vial.

Uplizna is approved to treat certain adults with a nerve condition that affects the eye and spinal cord called neuromyelitis optica spectrum disorder (NMOSD) as well as Immunoglobulin G4-related disease (IgG4-RD) in adult patients.

Uplizna is an anti-CD19 monoclonal antibody. It’s unclear how the medication works, but it’s thought to attach to CD19 proteins that are found on your B cells (a type of immune cell that plays a role in inflammation). Once attached, the medication destroys these B cells and lowers the amount of B cells in the body. This might help treat NMOSD, a condition that happens when the immune system attacks the nerves of the eye and spinal cord and causes swelling.

The typical dose of Uplizna is 300 mg given as an infusion into the vein (intravenously or IV). The first two doses are given 2 weeks apart. After that, you’ll get the 300 mg IV infusion every 6 months.

Uplizna is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Previous life-threatening reaction to an infusion of Uplinza
• Active hepatitis B infection
• Active or untreated latent tuberculosis

Common side effects of Uplizna:

• Urinary tract infection
• Common cold-like symptoms
• Infusion reaction (e.g., fever, muscle pain, nausea)
• Joint pain
• Headache

Serious side effects are rare with Uplizna. Contact your healthcare provider immediately if you experience any of the following:

• Serious infection: fever, chills, muscle aches, constant cough, sore throat, skin redness or swelling, diarrhea, burning feeling during urination
• Brain infection: weakness on one side of the body, loss of coordination in your arms or legs, vision changes, changes in thinking or memory, confusion, changes in personality
• Serious infusion reaction: headache, nausea, sleepiness, trouble breathing, fever, muscle aches, rash

The following medications may interact with Uplizna:

• Immunosuppressant drugs, including systemic
• Corticosteroids

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It is not known if Uplinza will harm your unborn baby. Females should use birth control (contraception) during treatment and for 6 months after your last infusion.

• Inebilizumab-Cdon