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Tyenne (tocilizumab-aazg) is a subcutaneous injection or IV infusion used to treat several inflammatory conditions in children and adults, including rheumatoid arthritis.

Tyenne is available as a 80 mg/4 mL (20 mg/mL), 200 mg/10 mL (20 mg/mL), 400 mg/20 mL (20 mg/mL) single-dose vial for intravenous infusion and a 162 mg/0.9 mL in a single-dose prefilled syringe or single-dose prefilled autoinjector.

Tyenne is an interleukin-6 (IL-6) receptor antagonist indicated for treatment of: Rheumatoid arthritis Giant cell arteritis (GCA) Polyarticular juvenile idiopathic arthritis (PJIA) Systemic juvenile idiopathic arthritis (SJIA)

In your body, the protein interleukin-6 (IL-6) acts as a key messenger in promoting inflammation. It binds to cells, signaling them to activate, which may contribute to the symptoms associated with RA. Tyenne targets this specific process. By binding to the IL-6 receptor, Tyenne blocks its interaction with cells, which is thought to reduce the signs and symptoms of RA.

Tyenne is given as a subcutaneous injection or IV infusion. Your dose will be decided based on how well it is working, your body weight, if it is given sub-Q or IV, and what side effects it it causing.

Tyenne is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are allergic to tocilizumab products.

Common side effects of Tyenne: Upper respiratory tract infections High blood pressure Headache Increased liver enzymes

Serious side effects are rare with Tyenne. Contact your healthcare provider immediately if you experience any of the following: Serious infections: fever, tiredness, chills, cough, trouble breathing Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing Worsening liver problems or liver failure: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

The following medications may interact with Tyenne: Omeprazole Warfarin Cyclosporine Theophylline Live vaccines

Fresenius Kabi

Tyenne may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with Tyenne.

• Tocilizumab-Aazg