tofacitinib
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Manufactured by various FDA-approved generic manufacturers.
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tofacitinib Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is tofacitinib available in?
tofacitinib is available as a 1 mg/mL oral solution.
What is tofacitinib used for?
tofacitinib is a Janus kinase (JAK) inhibitor that is used to treat:
- Moderate-to-severe rheumatoid arthritis (RA) in adults
Psoriatic arthritis (PsA) in adults - Ankylosing spondylitis (AS) in adults
- Moderate-to-severe ulcerative colitis (UC) in adults
- Moderate-to-severe polyarticular juvenile idiopathic arthritis (pJIA) in children ages 2 years and older – immediate-release tablets and liquid only
How does tofacitinib work?
tofacitinib is a Janus kinase (JAK) inhibitor. It blocks a protein in the body called JAK. This protein plays a role in causing inflammation. By blocking and stopping JAK from working, tofacitinib lowers inflammation in the body.
How do I take tofacitinib?
tofacitinib is dosed as follows:
- Rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis
- IR (immediate-release) tablets: The typical dose is 5 mg by mouth twice daily
- XR (extended-release) tablets: The typical dose is 11 mg by mouth once daily
Ulcerative colitis
- IR tablets: The typical dose is 10 mg by mouth twice daily for at least 8 weeks, then 5 mg by mouth twice daily
- XR tablets: The typical dose is 22 mg by mouth once daily for at least 8 weeks, then 11 mg by mouth once daily
Polyarticular course juvenile idiopathic arthritis
- IR tablets and liquid: The dose is based on your body weight. The typical dose ranges from 3.2 mg to 5 mg by mouth twice daily
Is it safe for me to take tofacitinib?
tofacitinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
tofacitinib Common Side Effects
Common side effects of tofacitinib:
- Arthritis:
- Upper respiratory tract infection
- Nose and throat infection
- Diarrhea
- Headache
Ulcerative colitis:
- Nose and throat infection
- High cholesterol
- Headache
- Upper respiratory tract infection
- Muscle damage
- Rash
- Diarrhea
- Stomach infection
- Anemia
tofacitinib Serious Side Effects
Serious side effects are rare with tofacitinib. Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: fever, weakness, chills, difficulty breathing, cough, diarrhea, stomach pain, burning when you urinate, urinating more or less often
- Stroke: sudden weakness on one side of your body, trouble speaking, confusion
- Blood clot near or in the heart: chest pain; short of breath; pain in the jaw, neck, or back; feeling weak or lightheaded
- Blood clot in the lung (pulmonary embolism): cough, chest pain, trouble breathing, racing heart
- Blood clot in the leg (deep vein thrombosis): leg cramp, swelling or pain in the leg, muscle tightness
Stomach tear: stomach pain, bloating, change in bowel movements, bleeding - Liver damage: nausea, stomach pain, yellowing of the skin or whites of the eyes
Severe allergic reaction: rash, trouble breathing, feeling faint, swelling of the face or throat - Cancer
Effects of other drugs, drug classes and over-the-counter products on tofacitinib
The following medications may interact with tofacitinib:
- Strong CP3A4 Inhibitors (e.g., ketoconazole): Dosage adjustment of XELJANZ/XELJANZ XR/XELJANZ Oral Solution is recommended
- Moderate CYP3A4 Inhibitors Coadministered with Strong CYP2C19 Inhibitors (e.g., fluconazole): Dosage adjustment of XELJANZ/XELJANZ XR/XELJANZ Oral Solution is recommended
- Strong CYP3A4 Inducers (e.g., rifampin): Coadministration with XELJANZ/XELJANZ XR/XELJANZ Oral Solution is not recommended
- Immunosuppressive Drugs (e.g., azathioprine, tacrolimus, cyclosporine): Risk of added immunosuppression; coadministration with biologic DMARDs or potent immunosuppressants has not been studied in patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, UC, or pcJIA
Who makes tofacitinib?
Various FDA-approved generic manufacturers
Is tofacitinib safe in pregnancy?
XELJANZ/XELJANZ XR/XELJANZ Oral Solution may affect the ability of females to get pregnant. It is not known if this will change after stopping XELJANZ/XELJANZ XR/XELJANZ Oral Solution. It is not known if XELJANZ/XELJANZ XR/XELJANZ Oral Solution will harm an unborn baby. Pregnancy Registry: Pfizer has a registry for pregnant women who take XELJANZ/XELJANZ XR/XELJANZ Oral Solution. The purpose of this registry is to check the health of the pregnant mother and her baby. If you are pregnant or become pregnant while taking XELJANZ/XELJANZ XR/XELJANZ Oral Solution, talk to your healthcare provider about how you can join this pregnancy registry or you may contact the registry at 1-877-311-8972 to enroll.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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