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Tivdak is the brand name for tisotumab vedotin-tftv and is available as an intravenous injection.

Tivdak is available as a 40 mg single-dose vial for reconstitution.

Tivdak is an antibody-drug conjugate. It’s used to treat advanced and metastatic cervical cancer when other medications haven’t worked well.

Tivdak Tivdak (tisotumab) is an antibody-drug conjugate (ADC). It’s made up of 2 main parts that work together to kill cancer cells:

• A monoclonal antibody part that finds and binds to cancer cells. In the case of cervical cancer, the monoclonal antibody binds to tissue factor (TF).
• Once Tivdak (tisotumab) is inside the tumor cells, the chemotherapy part of this medication kills the tumor cells.

The recommended dose of Tivdak is 2 mg/kg (up to a maximum of 200 mg) given as an intravenous infusion over 30 minutes every 3 weeks until disease progression or unacceptable toxicity.

Tivdak is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Tivdak:

• Low blood cell counts
• Tiredness
• Nausea
• Numbness or tingling in your hands and feet
• Nosebleeds
• Hair loss
• Eye irritation
• Bleeding
• Dry eyes
• Abnormal kidney and liver tests
• Rash
• Diarrhea
• Constipation
• Stomach pain
• Corneal problems
• Muscle pain

Serious side effects are rare with Tivdak. Contact your healthcare provider immediately if you experience any of the following:

• Nerve damage (neuropathy): tingling in the hands or feet, numbness, muscle weakness or twitching, loss of grip, loss of pain or touch
• Serious bleeds: bleeding or bruising that won’t stop or go away, blood in the urine, bloody or black and tarry stools, heavy vaginal bleeding, coughing up blood
• Lung problems: shortness of breath, cough, difficulty breathing
• Severe eye problems: vision changes, blurry vision, vision loss, corneal inflammation or ulcers, eyelid inflammation, dry eyes, red eyes
• Severe allergic or skin problems: rash, peeling of skin, hives, trouble breathing, painful sores or ulcers

The following medications may interact with Tivdak:

• Strong CYP3A4 inhibitors

Seagen

Tivdak can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment. Females who are able to become pregnant should do a pregnancy test before you start treatment with Tivdak. You should use an effective birth control during treatment and for 2 months after your last dose. Males with female partners who are able to become pregnant should use an effective birth control during treatment and for 4 months after your last dose.

• Tisotumab Vedotin-Tftv