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Teprotumumab-Trbw is available as 500 mg of Teprotumumab-Trbw in a single-dose vial for reconstitution.

Teprotumumab-Trbw is an insulin-like growth factor-1 receptor inhibitor indicated for the treatment of thyroid eye disease.

Teprotumumab-Trbw works by targeting the insulin-like growth factor-1 receptor (IGF-1R) on cells behind the eyes, which is overactive in thyroid eye disease (TED). By blocking this receptor, it reduces inflammation and swelling in the orbital tissues, leading to improvements in symptoms like eye bulging, redness, and double vision.

Teprotumumab-Trbw is given as 10 mg/kg for first infusion, followed by 20 mg/kg every 3 weeks for 7 additional infusions.

Teprotumumab-Trbw is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Teprotumumab-Trbw:

• Muscle spasm
• Nausea
• Hair loss
• Diarrhea
• Fatigue
• High blood sugar
• HHearing problems
• Dry skin
• Taste changes
• Headache
• Weight loss
• Nail disorder

Serious side effects are rare with Teprotumumab-Trbw. Contact your healthcare provider immediately if you experience any of the following:

• Infusion reactions
• Worsening inflammatory bowel disease (IBD)
• Serious hearing loss

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Teprotumumab-Trbw can cause harm to your unborn baby. Inform your healthcare provider of a known or suspected pregnancy. Females that can become pregnant should use effective contraception prior to initiation, during treatment, and for 6 months after the last dose.

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