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Stiolto Respimat is the brand name for tiotropium bromide and olodaterol and is available as an inhalation spray.

Stiolto Respimat is an inhalation spray. Each actuation delivers 2.5 mcg of tiotropium (equivalent to 3.124 mcg tiotropium bromide monohydrate), and 2.5 mcg of olodaterol (equivalent to 2.736 mcg olodaterol hydrochloride).

Stiolto Respimat is a combination inhaler containing two bronchodilators. It’s used to treat chronic obstructive pulmonary disease (COPD) in adults.

Stiolto Respimat is a combination of two medications that work together to help to open up your airways:

• Tiotropium is a long-acting muscarinic antagonist (LAMA), a type of anticholinergic medication. It helps you breathe better by blocking a chemical in your lungs called acetylcholine.
• Olodaterol is a long-acting beta agonist. It improves your breathing by relaxing the muscles in your airways.

Stiolto Respimat is taken as 2 inhalations once-daily at the same time of day.

Stiolto Respimat is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Use of a LABA without an inhaled corticosteroid is contraindicated in patients with asthma
• Hypersensitivity to tiotropium, ipratropium, olodaterol, or any component of this product

Common side effects of Stiolto Respimat:

• Nose and throat infection
• Cough
• Back pain

Serious side effects are rare with Stiolto Respimat. Contact your healthcare provider immediately if you experience any of the following:

• Sudden narrowing of your airways: difficulty breathing, wheezing, cough, chest pain or tightness
• Heart problems: dizziness, fatigue, weakness, tremor, irregular heartbeat, worsening symptoms of heart problem that you already have
• Serious allergic reaction: hives; swelling of your face, lips, or tongue; difficulty breathing

The following medications may interact with Stiolto Respimat:

• Other adrenergic drugs
• Xanthine derivatives, steroids, diuretics, or non-potassium sparing diuretics
• MAO inhibitors, tricyclic antidepressants, and drugs that prolong the QTc interval
• Beta-blockers
• Anticholinergics

Boehringer Ingelheim Pharmaceuticals, Inc.

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Tiotropium Bromide And Olodaterol