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Sitagliptin is available as a 25 mg, 50 mg, and 100 mg oral tablet.

Sitagliptin is a DDP-4 inhibitor and is used to treat type 2 diabetes in adults.

Sitagliptin is a DPP-4 inhibitor, which means that it blocks the action of DPP-4. In doing so, Sitagliptin allows insulin to stick around longer in your body and tells your body to make less sugar. These actions lower your blood sugar levels.

Sitagliptin is typically dosed as 100 mg by mouth once daily. Your dose might differ if you have kidney problems

Sitagliptin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Sitagliptin:

• Runny nose, sore throat, and other symptoms of the common cold

Serious side effects are rare with Sitagliptin. Contact your healthcare provider immediately if you experience any of the following.

• Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
• Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling
• Sudden kidney problems: not urinating, swelling in legs or ankles, feeling tired, trouble breathing, confusion, nausea

The following medications may interact with Sitagliptin:

• Insulin Secretagogues or Insulin: Coadministration of Sitagliptin with an insulin secretagogue (e.g., sulfonylurea) or insulin may require lower doses of the insulin secretagogue or insulin to reduce the risk of hypoglycemia

Various FDA-approved generic manufacturers

It is not known if Sitagliptin can harm your unborn baby. Sitagliptin should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.

• Januvia