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Manufactured by Janssen Pharmaceuticals

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

SIMPONI ARIA Uses, Side Effects, Interactions, Warnings & Dosing



SIMPONI ARIA is the brand name for golimumab and is available as an injection for IV use.

What dosages is SIMPONI ARIA available in?

What dosages is SIMPONI ARIA available in?

SIMPONI ARIA is available as a 50 mg/4 mL (12.5 mg/mL) injection for IV use.

What is SIMPONI ARIA used for?

What is SIMPONI ARIA used for?

SIMPONI ARIA is a monoclonal antibody that is used to treat:

  • Ankylosing spondylitis (AS, a condition that causes pain, swelling, and stiffness in your spine)
  • Psoriatic arthritis (PsA)
  • Rheumatoid arthritis (RA)
  • Childhood arthritis (pJIA, polyarticular juvenile idiopathic arthritis) – Simponi Aria only
  • Ulcerative colitis (UC, a condition that causes pain, swelling, and sores in your gut) when other medications haven’t worked well – Simponi only
How does SIMPONI ARIA work?

How does SIMPONI ARIA work?

SIMPONI ARIA is a monoclonal antibody that blocks a protein called tumor necrosis factor (TNF) in your body. By blocking TNF, it lowers inflammation in your body to treat pain and swelling in your joints and gut caused by autoimmune conditions.

How do I take SIMPONI ARIA?

How do I take SIMPONI ARIA?

SIMPONI ARIA is dosed as follows:

  • Adult patients with Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing
  • Spondylitis: 2 mg/kg intravenous infusion over 30 minutes at weeks 0 and 4, and every 8 weeks thereafter
  • Pediatric patients with polyarticular Juvenile Idiopathic Arthritis and Psoriatic Arthritis: 80 mg/m2 intravenous infusion over 30 minutes at weeks 0 and 4, and every 8 weeks thereafter
Is it safe for me to take SIMPONI ARIA?

Is it safe for me to take SIMPONI ARIA?

SIMPONI ARIA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

SIMPONI ARIA Common Side Effects

SIMPONI ARIA Common Side Effects

Common side effects of SIMPONI ARIA:

  • Upper respiratory tract infection (cough, sore throat, runny nose)
  • Pain, bruising, itching, rash, hardness, redness, or burning at the injection site
  • Viral infections (e.g., flu)
  • Liver injury
  • High blood pressure
SIMPONI ARIA Serious Side Effects

SIMPONI ARIA Serious Side Effects

Serious side effects are rare with SIMPONI ARIA. Contact your healthcare provider immediately if you experience any of the following.

  • Serious infections: fever, difficulty breathing, cough that won’t go away, night sweats, confusion, feeling very tired, diarrhea, stomach pain, vomiting, muscle aches, chills, yellowing of the skin or eyes
  • Serious allergic reactions: hives, itching, swelling of face or tongue, difficulty breathing
  • Cancer: loss of appetite, feeling very tired, lumps on skin, swollen lymph nodes in your neck, armpits, or groin, weight loss, difficulty breathing, chills, fever
Effects of other drugs, drug classes and over-the-counter products on SIMPONI ARIA

Effects of other drugs, drug classes and over-the-counter products on SIMPONI ARIA

The following medications may interact with SIMPONI ARIA:

  • Abatacept: Increased risk of serious infection
  • Anakinra: Increased risk of serious infection
  • Live vaccines/therapeutic infectious agents: Avoid use with SIMPONI ARIA


Janssen Pharmaceuticals

Is SIMPONI ARIA safe in pregnancy?

Is SIMPONI ARIA safe in pregnancy?

There are no adequate and well-controlled trials of SIMPONI ARIA in pregnant women. However, infants born to women treated with SIMPONI ARIA during their pregnancy may be at increased risk of infection for up to 6 months.


What to do if you missed your SIMPONI ARIA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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