ROZLYTREK
Used for Cancer
NowPatient can significantly lower the cost* of your prescription medication by providing free access to drug coupons, savings cards, patient assistance programs and other out of pocket discount programs. Whether you’re insured, uninsured, or underinsured, we empower you with transparency and cost-saving tools to make your ROZLYTREK more affordable.
Manufactured by Genentech, Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ROZLYTREK key facts
What is ROZLYTREK?
ROZLYTREK is the brand name for entrectinib oral capsules and pellets.
What dosages is ROZLYTREK available in?
ROZLYTREK is available as a 100 mg and 200 mg oral capsule and 50 mg per packet of pellets.
What is ROZLYTREK used for?
ROZLYTREK is a tyrosine kinase inhibitor that is used to treat:
Metastatic non-small cell lung cancer (NSCLC) with ROS1 gene changes Advanced and metastatic cancers with NTRK gene changes, when prior treatment hasn’t worked and no other treatment is available
How does ROZLYTREK work?
Certain types of cancer have changes in the NTRK and ROS1 genes. These changes result in abnormal proteins called NTRK fusions and ROS1 fusions that can send signals for tumors to grow. ROZLYTREK works by attaching to these abnormal proteins and blocking the tumors from growing and spreading.
How do I take ROZLYTREK?
ROZLYTREK is typically dosed as follows: NSCLC with ROS1 mutations Adults: The typical dose is 600 mg by mouth once a day.
Cancers with NTRK gene changes
- Adults: The typical dose is 600 mg by mouth once a day
- Children (ages 12 years and older): Your child’s provider will calculate the dose based on your child’s body surface area (BSA), which takes into account their height and weight. The typical dose ranges between 400 mg to 600 mg by mouth once a day
Is it safe for me to take ROZLYTREK?
ROZLYTREK is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ROZLYTREK Common Side Effects
Common side effects of ROZLYTREK:
- Lower blood cell counts
- Feeling very tired
- Constipation
- Changes in taste
- Swelling
- Dizziness
- Diarrhea
- Nausea
- Feeling numbness, pain, or tingling
- Trouble catching your breath
ROZLYTREK Serious Side Effects
Serious side effects are rare with ROZLYTREK. Contact your healthcare provider immediately if you experience any of the following.
- Hallucinations and confusion
- Depression and thoughts of self-harm
- Serious eye problems: changes in vision, blurry vision
- Heart problems: feeling lightheaded, trouble catching your breath, racing heartbeat, swelling in the legs
- Broken bones: muscle or bone pain, changes in mobility
- Serious liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
Effects of other drugs, drug classes and over-the-counter products on ROZLYTREK
The following medications may interact with ROZLYTREK:
- Moderate and Strong CYP3A Inhibitors: For adult and pediatric patients 2 years and older, reduce the dose of
- ROZLYTREK if coadministration of moderate or strong CYP3A inhibitors cannot be avoided. For pediatric patients less than 2 years, avoid coadministration with ROZLYTREK
- Moderate and Strong CYP3A Inducers: Avoid coadministration with ROZLYTREK
- Drugs That Prolong QTc Interval: Avoid concomitant use with ROZLYTREK
Who makes ROZLYTREK?
Genentech, Inc.
Is ROZLYTREK safe in pregnancy?
ROZLYTREK can cause harm to your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ROZLYTREK. Females who can become pregnant: Your healthcare provider will do a pregnancy test before you start treatment with ROZLYTREK. Use effective birth control (contraception) during treatment with ROZLYTREK and for at least 5 weeks after the last dose. Males with female partners that can become pregnant: Use effective birth control (contraception) during treatment with ROZLYTREK and for 3 months after the last dose.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ROZLYTREK prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ROZLYTREK prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ROZLYTREK savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ROZLYTREK savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ROZLYTREK | Canadian Prescription Savings* for ROZLYTREK | ROZLYTREK Drug Coupon* | ROZLYTREK Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ROZLYTREK?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ROZLYTREK | Canadian Prescription Savings* for ROZLYTREK | ROZLYTREK Drug Coupon* | ROZLYTREK Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ROZLYTREK savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ROZLYTREK drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ROZLYTREK, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ROZLYTREK prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ROZLYTREK is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ROZLYTREK for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ROZLYTREK prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ROZLYTREK prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ROZLYTREK
If you are having trouble paying for your ROZLYTREK medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ROZLYTREK you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ROZLYTREK is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ROZLYTREK
- If ROZLYTREK is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ROZLYTREK
If you are having trouble paying for your ROZLYTREK medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ROZLYTREK you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ROZLYTREK
- If ROZLYTREK is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ROZLYTREK
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ROZLYTREK treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ROZLYTREK you will need to meet the following criteria:
- You must be currently insured and have coverage for ROZLYTREK
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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