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Rituximab is available as a 100 mg/10 mL (10 mg/mL) and 500 mg/50 mL (10 mg/mL) single-dose vial.

Rituximab is monoclonal antibody that is used to treat:

Blood cancers

• Certain types of CD20-positive non-Hodgkin’s lymphoma (NHL) in adults and children ages 6 months and older
• CD20-positive chronic lymphocytic leukemia (CLL) in adults

Autoimmune conditions

• Moderate to severe rheumatoid arthritis (RA) in adults
  Granulomatosis with polyangitis (GPA) and microscopic polyangitis (MPA) in adults and children ages 2 years and older
• Moderate to severe pemphigus vulgaris in adults

Rituximab is a monoclonal antibody. It targets specific immune cells called B cells that can be involved in a range of different health conditions. For example, B cells sometimes turn into cancer cells. Other times, they become overly active and cause autoimmune conditions. Rituximab works by attaching a specific protein on the B cells called CD20. When it does so, it signals to the body to attack and kill that cell. As a result, these abnormal or overly active B cells can’t grow, spread, or work as well.

Your provider will determine your dose of Rituximab based on your body surface area (BSA) in m². This medication is typically given by a healthcare provider in a hospital or infusion clinic setting. Your provider might also give you other anticancer medications along with Rituximab.

Rituximab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Rituximab:

• Fever
• Lower white blood cell counts
• Chills
• Infection
• Weakness
• Nausea
• Headache
• Night sweats
• Rash

Serious side effects are rare with Rituximab. Contact your healthcare provider immediately if you experience any of the following.

• Infusion-related reaction: swelling, trouble breathing, chest pain, low blood pressure, red skin
• Serious skin reaction: painful blisters, skin wounds, peeling skin, fever, sore throat, body aches
• Tears in the gut: sudden and severe stomach pain, fever, chills, and nausea or vomiting that won’t go away
• Infection: fever, chills, cough, muscle aches, very fast heartbeat, severe tiredness
• Tumor lysis syndrome: seizures, hallucinations, nausea, tiredness, no appetite, dark-colored urine, muscle cramps, numbness
• Serious heart problems: tiredness, weakness, dizziness, feeling faint, trouble breathing, pressure on the chest, pounding heart, irregular heart beat, sweating, feeling anxious, nausea

The following medications may interact with Rituximab:

• Renal toxicity when used in combination with cisplatin

Various FDA-approved generic manufacturers

Talk to your healthcare provider about the risks to your or your child’s unborn baby if you or your child receive Rituximab during pregnancy. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test to see if you or your child are pregnant before starting
Rituximab. You or your child should use effective birth control (contraception) during treatment with Rituximab and for 12 months after your or your child’s last dose of Rituximab. Talk to your healthcare provider about effective birth control.
Tell your healthcare provider right away if you or your child become pregnant or think that you or your child are pregnant during treatment with Rituximab.

• Rituxan