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Ripretinib is available as a 50 mg oral tablet.

Ripretinib is a kinase inhibitor used to treat adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.

Ripretinib is a kinase inhibitor that works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

The typical dose of Ripretinib is 150 mg by mouth once daily with or without food.

Ripretinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Ripretinib:

• Hair loss
• Fatigue
• Nausea,
• Abdominal pain
• Constipation
• Muscle pain
• Diarrhea
• Decreased appetite
• Vomiting

Serious side effects are rare with Ripretinib. Contact your healthcare provider immediately if you experience any of the following:

• Palmar-plantar erythrodysesthesia syndrome (hand-foot syndrome): redness, swelling, pain, and sometimes peeling or blistering on the palms of the hands and soles of the feet
• High blood pressure
• Slowed wound healing

The following medications may interact with Ripretinib:

• CYP3A inhibitors and inducers

Various FDA-approved generic manufacturers

Based on animal studies and its mechanism of action, Ripretinib can cause harm to your unborn baby. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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