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Manufactured by various FDA-approved generic manufacturers.

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riociguat Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is riociguat available in?

What dosages is riociguat available in?

riociguat is available as a 0.5 mg, 1 mg, 1.5 mg, 2 mg and 2.5 mg oral tablet.

What is riociguat used for?

What is riociguat used for?

riociguat is a soluble guanylate cyclase (sGC) stimulator and is used for the following:

  • Pulmonary arterial hypertension (PAH) in adults
  • Chronic thromboembolic pulmonary hypertension (CTEPH) in adults
How does riociguat work?

How does riociguat work?

riociguat is a soluble guanylate cyclase (sGC) stimulator. It works by activating sGC, a protein that helps relax the blood vessels in the lungs and allows more blood to flow through. As a result, your heart is able to pump better, your body gets more oxygen, and you should be able to breathe and exercise easier.

How do I take riociguat?

How do I take riociguat?

The typical starting dose is 0.5 mg to 1 mg by mouth 3 times a day. If needed, your provider will raise your dose every 2 weeks. The maximum dose is 2.5 mg by mouth 3 times a day. Your provider will adjust your dose based on how well it’s helping your condition, if you’re having side effects, if you’re taking a medication that interacts with riociguat, and if you smoke.

Is it safe for me to take riociguat?

Is it safe for me to take riociguat?

riociguat is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have the following.

  • Pregnancy
  • Use with nitrates or nitric oxide donors in any form
  • Use with PDE inhibitors
  • Patients with concomitant use of other soluble guanylate cyclase (sGC) stimulators
  • Pulmonary hypertension associated with idiopathic interstitial pneumonias (PH-IIP)
riociguat Common Side Effects

riociguat Common Side Effects

Common side effects of riociguat:

  • Headache
  • Indigestion or stomach irritation
  • Dizziness
  • Nausea
  • Diarrhea
  • Low blood pressure
  • Vomiting
  • Anemia
  • Reflux or heartburn
  • Constipation
riociguat Serious Side Effects

riociguat Serious Side Effects

Serious side effects are rare with riociguat. Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
  • Severe bleeding: feeling faint, lightheadedness, dizziness, vomiting blood, bloody or dark-colored stools, severe stomach pain or discomfort
  • Blockage in the lungs: dizziness, trouble breathing, irregular heartbeat, chest pain, sweating, coughing
Effects of other drugs, drug classes and over-the-counter products on riociguat

Effects of other drugs, drug classes and over-the-counter products on riociguat

The following medications may interact with riociguat:

  • Strong CYP and P-gp/BCRP inhibitors: For patients receiving strong CYP and P-gp/BCRP inhibitors, consider a starting dose of 0.5 mg three times a day. Monitor for hypotension
  • Antacids: Separate administration by at least 1 hour
Who makes riociguat?

Who makes riociguat?

Various FDA-approved generic manufacturers

Is riociguat safe in pregnancy?

Is riociguat safe in pregnancy?

riociguat can cause serious birth defects if taken during pregnancy. Females must not be pregnant when they start taking riociguat or become pregnant during treatment with riociguat. Females who are able to get pregnant must use 2 acceptable forms of birth control, during treatment with riociguat and for 1 month after stopping riociguat because the medicine may still be in the body.


What to do if you missed your riociguat dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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