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regorafenib

regorafenib

Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

regorafenib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is regorafenib available in?

What dosages is regorafenib available in?

regorafenib is available as a 40 mg oral tablet.

What is regorafenib used for?

What is regorafenib used for?

regorafenib is a kinase inhibitor indicated for the treatment of patients with:

  • Metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an antiVEGF therapy, and, if RAS wild-type, an anti-EGFR therapy.
  • Locally advanced, unresectable or metastatic gastrointestinal stromal tumor
    (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.
  • Hepatocellular carcinoma (HCC) who have been previously treated with sorafenib
How does regorafenib work?

How does regorafenib work?

regorafenib works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

How do I take regorafenib?

How do I take regorafenib?

The recommended dose of regorafenib is 160 mg orally, once daily for the first 21 days of each 28-day cycle after a low-fat meal.

Is it safe for me to take regorafenib?

Is it safe for me to take regorafenib?

regorafenib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

regorafenib Common Side Effects

regorafenib Common Side Effects

Common side effects of regorafenib:

  • Pain (including gastrointestinal and abdominal pain)
  • Asthenia/fatigue
  • Diarrhea
  • Decreased appetite/food intake
  • Hypertension
  • Infection
  • Fever
  • Weight loss
  • Rash
  • Nausea
regorafenib Serious Side Effects

regorafenib Serious Side Effects

Serious side effects are rare with regorafenib. Contact your doctor if you experience any of the following.

  • Infections
  • Severe bleeding
  • Severe skin rash
  • Tear in your stomach
  • Heart attack
  • Wound healing problems
Effects of other drugs, drug classes and over-the-counter products on regorafenib

Effects of other drugs, drug classes and over-the-counter products on regorafenib

The following medications may interact with regorafenib:

  • Strong CYP3A4 inducers: Avoid strong CYP3A4 inducers
  • Strong CYP3A4 inhibitors: Avoid strong CYP3A4 inhibitors
  • BCRP substrates: Monitor patients closely for symptoms of increased exposure to BCRP substrates
Who makes regorafenib?

Who makes regorafenib?

Various FDA-approved generic manufacturers

Is regorafenib safe in pregnancy?

Is regorafenib safe in pregnancy?

regorafenib can harm your unborn baby. Females should use effective birth control during treatment with regorafenib and for 2 months after your final dose of regorafenib. Tell your healthcare provider right away if you become pregnant during treatment with regorafenib or within 2 months after your final dose of regorafenib. Males with female partners who can become pregnant should use effective birth control during treatment with regorafenib and for 2 months after your final dose of regorafenib.

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What to do if you missed your regorafenib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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