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Rebif is the brand name for interferon beta-1a and is available as a subcutaneous injection.

Rebif is available as a single-dose prefilled syringe and single-dose prefilled syringe in strengths of 8.8 mcg in 0.2 mL, and 22 mcg or 44 mcg in 0.5 mL.

Rebif is an injectable biologic used for the treatment of relapsing forms of multiple sclerosis (MS).

Rebif is a biologic medication. Interferons typically attach to certain proteins and affect cell processes. It’s not known exacty how Rebif helps treat multiple sclerosis.

The recommended dose of Rebif is either 22 mcg or 44 mcg injected subcutaneously three times per week.

Rebif is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• History of hypersensitivity to natural or recombinant interferon beta,
• Human albumin, or any other component of the formulation

Common side effects of Rebif:

• Injection-site reactions
• Headache
• Flu-like symptoms
• Fatigue
• Fever
• Muscle pain
• Stomach pain

Serious side effects are rare with Rebif. Contact your healthcare provider immediately if you experience any of the following:

• Liver damage: severe stomach pain, pale stools, dark urine, yellowing of your skin or eyes
• Chest pain
• Infection at injection site
• Abnormal bleeding
• Seizures

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Merck & Co., Inc.

Rebif may cause harm to your unborn baby based on animal data. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Interferon Beta-1a