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Ravulizumab-Cwvz is available as a 300 mg/3 mL (100 mg/mL) and 1,100 mg/11 mL (100 mg/mL) solution in a single-dose vial.

Ravulizumab-Cwvz is a complement inhibitor indicated for:

• Paroxysmal nocturnal hemoglobinuria (PNH) in adults and children ages 1 month and older
• Atypical hemolytic uremic syndrome (aHUS) in adults and children ages 1 month and older
• Generalized myasthenia gravis (gMG) in adults
• Neuromyelitis optica spectrum disorder (NMOSD) in adults

Ravulizumab-Cwvz is a monoclonal antibody that works as an complement inhibitor. The exact way that the medication works isn’t completely clear. But it’s thought to block complement proteins called C5. This helps stop your immune system from being overactive and from attacking different parts of your body.

Treatment starts with a loading dose of Ravulizumab-Cwvz. It then continues with routine maintenance doses, generally starting 2 weeks after the loading dose, and given every 1 or 2 months.

Ravulizumab-Cwvz is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Patients with unresolved serious Neisseria meningitidis infection

Common side effects of Ravulizumab-Cwvz:

• Upper respiratory tract infection
• Headache
• Diarrhea
• Nausea
• Vomiting
• High blood pressure
• Joint pain
• Fever
• Cough
• Shortness of breath
• Swelling in arms or legs
• Urinary tract infection

Serious side effects are rare with Ravulizumab-Cwvz. Contact your healthcare provider immediately if you experience any of the following:

• Serious infections (including meningococcal infections): fever, weakness, chills, trouble breathing, cough, diarrhea, stomach pain, burning when you urinate, urinating more or less often, neck pain, neck stiffness, confusion, severe headache
• Severe allergic reaction: rash, trouble breathing, feeling faint, swelling of the face or throat

The following medications may interact with Ravulizumab-Cwvz:

• Plasma exchange, plasmapheresis, or IV immunoglobulins
• Neonatal Fc receptor blockers

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Ultomiris