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Rasburicase is available as a 1.5 mg and 7.5 mg powder per single-use vial.

Rasburicase is an enzyme used for the managment of plasma uric acid levels in pediatric and adult patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anti-cancer therapy expected to result in tumor lysis and subsequent elevation of plasma uric acid.

Rasburicase is a medication used to lower uric acid levels in people receiving anticancer treatments. It’s an enzyme, which is a type of protein, that breaks down uric acid in your body.

Rasburicase is given as an injection through the veins (IV). It’s typically given to people in the hospital by a healthcare provider. Your provider will determine the right dose for you. You’ll typically receive one Rasburicase IV infusion daily for up to 5 days.

Rasburicase is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have the following. History of the following reactions to Rasburicase: anaphylaxis, severe hypersensitivity, hemolysis, methemoglobinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Common side effects of Rasburicase:

• Nausea
• Vomiting
• Swelling of the arms or legs
• Anxiety
• Headache
• Stomach pain
• Throat pain

Serious side effects are rare with Rasburicase. In some people who lack a specific enzyme, Rasburicase can cause your red blood cells to break down too quickly. When you have low red blood cells, you can feel tired, weak, dizzy, or have pale skin. Your provider might do a blood test to check if you’re missing this enzyme. If you are, you can’t take this medication. Rasburicase might also cause a serious condition known as methemoglobinemia. This causes the blood to be unable to deliver oxygen to the body well. The signs of this reaction are pale-, gray-, or blue-colored skin, headache, irregular heart rate, trouble breathing, dizziness, or tiredness. Make sure to get medical help right away if you experience any symptoms of a serious side effect.

• No drug interaction studies have been conducted in humans. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

Rasburicase may cause fetal harm. Use only if the potential benefit to the mother justifies the potential risk to the fetus.

• Elitek