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Pyzchiva (ustekinumab-ttwe) is a biosimilar medication that is available as a subcutaneous injection and IV infusion.

Pyzchiva is available as 45 mg/0.5 mL and 90 mg/mL pre-filled syringes for subcutaneous injection and 130 mg/26 mL (5 mg/mL) single-dose vial for intravenous infusion.

Pyzchiva is a human interleukin (IL)-12 and IL-23 antagonist that is used to treat adult patients with moderate to severe plaque psoriasis, active psoriatic arthritis, moderately to severely active Crohn ‘s disease and moderately to severely active ulcerative colitis, as well as pediatric patients with moderate to severe plaque psoriasis and active psoriatic arthritis.

Pyzchiva is an interleukin antagonist that blocks proteins in your immune system called interleukin-12 (IL-12) and interleukin-23 (IL-23) from working. This helps to lower inflammation and treat symptoms caused by autoimmune conditions.

Pzychiva is given as a subcutaneous injection or IV infusion. Your dose will be based on your weight and the condition being treated.

Pzychiva is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Pzychiva is you are allergic to ustekinumab products or to any of the inactive ingredients in the product.

Common side effects of Pzychiva: Common cold symptoms Upper respiratory tract infections Headache Fatigue Vomiting Injection site reactions Stomach pain Nausea

Serious side effects are rare with Pzychiva. Contact your healthcare provider immediately if you experience any of the following: Serious infections: fever, chills, muscle aches, diarrhea, or feeling very tired Cancer, including skin cancer: new skin growths and changes to your skin Posterior reversible encephalopathy syndrome (PRES): headache, confusion, visual changes, and seizures Swelling in the lungs: coughing and trouble breathing

The following medications may interact with Pzychiva: CYP450 substrates: consider monitoring for therapeutic effect (e.g., for warfarin) or drug concentration (e.g., for cyclosporine) and adjust the individual dose of the drug as needed live vaccines

Samsung Bioepis Co., Ltd.

It is not known whether Pzychiva will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.

• Ustekinumab-TTWE