POLIVY
Used for Cancer
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Manufactured by Genentech, Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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POLIVY Uses, Side Effects, Interactions, Warnings & Dosing
What is POLIVY?
POLIVY is the brand name for polatuzumab vedotin-piiq IV infusion.
What dosages is POLIVY available in?
POLIVY is available as a 30 mg or 140 mg single-dose vial.
What is POLIVY used for?
POLIVY is a CD79b-directed antibody and microtubule inhibitor conjugate indicated: In combination with a rituximab product, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for the treatment of adult patients who have previously untreated diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) or high-grade B-cell lymphoma (HGBL) and who have an International Prognostic Index score of 2 or greater. In combination with bendamustine and a rituximab product for the treatment of adult patients with relapsed or refractory DLBCL, NOS, after at least two prior therapies.
How does POLIVY work?
POLIVY works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
How do I take POLIVY?
The recommended dose of POLIVY is 1.8 mg/kg as an intravenous infusion every 21 days for 6 cycles.
Is it safe for me to take POLIVY?
POLIVY is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
POLIVY Common Side Effects
Common side effects of POLIVY:
- Diarrhea
- Dizziness
- Loss of appetite
- Vomiting
- Weight loss
POLIVY Serious Side Effects
Serious side effects are rare with POLIVY. Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dizziness, loss of balance or coordination, confusion or trouble speaking
- Infection—fever, chills, cough, sore throat, wounds that don’t heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue - Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Pain, tingling, or numbness in the hands or feet
- Stomach pain, unusual weakness or fatigue, nausea, vomiting, diarrhea, or fever that lasts longer than expected
- Tumor lysis syndrome (TLS)—nausea, vomiting, diarrhea, decrease in the amount of urine, dark urine, unusual weakness or fatigue, confusion, muscle pain or cramps, fast or irregular heartbeat, joint pain
- Unusual bruising or bleeding
Effects of other drugs, drug classes and over-the-counter products on POLIVY
The following medications may interact with POLIVY:
- Concomitant use of strong CYP3A inhibitors or inducers has the potential to affect the exposure to unconjugated monomethyl auristatin E (MMAE)
Who makes POLIVY?
Genentech, Inc.
Is POLIVY safe in pregnancy?
POLIVY can cause harm to your unborn baby when administered during pregnancy. You should take a pregnancy test prior to the initiation of POLIVY. Females of reproductive potential to use effective contraception during treatment and for
3 months following the last dose of POLIVY.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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