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Plegridy is the brand name for peginterferon beta-1a and is available for for subcutaneous or intramuscular use.

Plegridy is available as a 63 mcg/0.5 mL, 94 mcg/0.5 mL, 125 mcg/0.5 mL single-dose prefilled pen or single-dose prefilled syringe.

Plegridy is an interferon beta used to treat relapsing forms of multiple sclerosis (MS) in adults.

Plegridy is an interferon beta. The exact way Plegridy treats MS isn’t well-understood. But it’s thought to work by calming down the immune system so that it’s less likely to attack the nervous system.

The typical starting dose is 63 mcg injected on Day 1, then 94 mcg on Day 15. Starting Day 29, the typical dose is to inject 125 mcg every 2 weeks thereafter.

Plegridy is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• History of hypersensitivity to natural or recombinant interferon beta or peginterferon, or any other component in the product

Common side effects of Plegridy:

• Injection-site redness
• Flu-like symptoms
• Fever
• Headache
• Muscle pain
• Chills
• Injection-site reactions
• Weakness
• Joint pain

Serious side effects are rare with Plegridy. Contact your healthcare provider immediately if you experience any of the following:

• Depression and thoughts of self-harm
• Seizures
• Serious allergic reactions: hives, itching, swelling of face or tongue, difficulty breathing
• Liver damage: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion
• Heart failure: shortness of breath, swelling in legs, ankles, or feet, coughing, fatigue, weakness
• High blood pressure in the lungs: shortness of breath, fatigue, swelling, chest pain, lips and fingers turning blue
• Low blood cell counts: fever, pale skin, fast heart rate, lightheadedness, easy bleeding or bruising

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Biogen, Inc.

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Peginterferon Beta-1a