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Pirtobrutinib is available as

• Pirtobrutinib ****

Pirtobrutinib works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

• Pirtobrutinib is typically dosed at 200 mg orally once daily with water and with or without food. Your dose may be reduced if you have severe kidney problems.

Pirtobrutinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Pirtobrutinib:

• Fatigue
• Musculoskeletal pain
• Diarrhea
• COVID-19
• Bruising
• Cough

Serious side effects are rare with Pirtobrutinib. Contact your healthcare provider if you have any of the following:

• Infection
• Bleeding problems (hemorrhage)
• Heart rhythm problems
• Symptoms of a second primary cancer

The following medications may interact with Pirtobrutinib:

• Strong CYP3A Inhibitors: Avoid concomitant use. If concomitant use is unavoidable, reduce the Pirtobrutinib dose
• Strong or Moderate CYP3A Inducers: Avoid concomitant use. If concomitant use of moderate CYP3A inducers is unavoidable, increase the Pirtobrutinib dose
• Sensitive CYP2C8, CYP2C19, CYP3A, P-gp, or BCRP Substrates: For substrates where minimal concentration changes may increase the risk of adverse reactions, follow recommendations for co-administration with CYP2C8, CYP2C19, CYP3A, P-gp, or BCRP inhibitors provided in their approved product labeling

Various FDA-approved generic manufacturers

Based on findings in animals, Pirtobrutinib can cause fetal harm when administered to a pregnant woman. If you can become pregnant you should use effective contraception during treatment with Pirtobrutinib and for one week after the last dose.

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