Used for Cancer

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Manufactured by Genentech, Inc.

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

PERJETA Uses, Side Effects, Interactions, Warnings & Dosing

What is PERJETA?

What is PERJETA?

PERJETA is the brand name for pertuzumab IV infusion.

What dosages is PERJETA available in?

What dosages is PERJETA available in?

PERJETA is available as a 420 mg/14 mL single-dose vial.

What is PERJETA used for?

What is PERJETA used for?

PERJETA is a HER2 receptor antagonist that is used to treat HER2-positive breast cancers, together with Herceptin (trastuzumab) and chemotherapy.

How does PERJETA work?

How does PERJETA work?

PERJETA is a monoclonal antibody that acts as a human epidermal growth factor receptor 2 (HER2) inhibitor. It blocks a specific protein in the body that’s important for cell growth called HER2. HER2 is found on both normal and cancer cells. Cancer cells usually have more HER2 proteins than normal cells. This can cause cancer cells to grow more quickly than normal cells. When HER2 is blocked by PERJETA, cancer cells can’t grow and spread as well.

How do I take PERJETA?

How do I take PERJETA?

PERJETA is given by a healthcare provider as an injection into a vein (intravenously or IV). The typical dose is 840 mg IV for the first infusion, and then 420 mg given once every 3 weeks.

Is it safe for me to take PERJETA?

Is it safe for me to take PERJETA?

PERJETA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

PERJETA Common Side Effects

PERJETA Common Side Effects

Common side effects of PERJETA:

  • Diarrhea
  • Nausea
  • Hair loss
  • Fatigue
  • Nerve problems in hands or feet (tingling or numbing sensation)
  • Weakness or lack of energy
  • Vomiting
  • Constipation
  • Anemia
  • Mucosal inflammation (mouth sores, mouth or gut inflammation)
  • Rash
  • Muscle pain
PERJETA Serious Side Effects

PERJETA Serious Side Effects

Serious side effects are rare with PERJETA. Contact your healthcare provider immediately if you experience any of the following.

  • Infusion-related or allergic reactions: fever, chills, dizziness, nausea, headache, sweating, rash, swelling of the face or throat, trouble breathing
  • Heart problems: shortness of breath; dry cough; swelling of legs, arms, or face; irregular heartbeats; dizziness; sudden weight gain
Effects of other drugs, drug classes and over-the-counter products on PERJETA

Effects of other drugs, drug classes and over-the-counter products on PERJETA

  • There are no major drug interactions listed for PERJETA. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes PERJETA?

Who makes PERJETA?

Genentech, Inc.

Is PERJETA safe in pregnancy?

Is PERJETA safe in pregnancy?

Based on the mechanism of action and animal data, PERJETA can cause embryo-fetal harm when administered during pregnancy. Advise females of reproductive potential to use effective contraception during treatment and for 7 months following the last dose of PERJETA in combination with trastuzumab.


What to do if you missed your PERJETA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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