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Patisiran is available as a 10 mg/5 mL (2 mg/mL) single-dose vial.

Patisiran is a medication used for treating nerve damage (polyneuropathy) due to hereditary transthyretin-mediated amyloidosis (hATTR).

Patisiran is a type of molecule called an small interfering ribonucleic acid (siRNA). It’s a piece of genetic material that attaches to the TTR gene and breaks it down. This lowers the amount of misshapened TTR proteins in your body, which lowers the amount of amyloid that builds up in your organs.

For patients weighing less than 100 kg, the recommended dosage is 0.3 mg/kg every 3 weeks by intravenous infusion. For patients weighing 100 kg or more, the recommended dosage is 30 mg.

Patisiran is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Patisiran:

• Upper respiratory infections
• Infusion-related reactions
• Indigestion
• Shortness of breath
• Muscle spasms
• Joint pain
• Skin redness
• Bronchitis
• Vertigo or a spinning sensation

Serious side effects are rare with Patisiran. Contact your healthcare provider immediately if you experience any of the following:

• Reduced vitamin A levels

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you. If you’re pregnant and are prescribed Patisiran or if you become pregnant while taking this medication, it’s recommended you enroll in a pregnancy registry that monitors your and your baby’s health outcomes.

• Onpattro