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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

OXBRYTA ODT Uses, Side Effects, Interactions, Warnings & Dosing



OXBRYTA ODT is the brand name for voxelotor and is available as an orally disintegrating tablet.

What dosages is OXBRYTA ODT available in?

What dosages is OXBRYTA ODT available in?

OXBRYTA ODT is available as a 300 mg orally disintegrating tablet.

What is OXBRYTA ODT used for?

What is OXBRYTA ODT used for?

OXBRYTA ODT is a hemoglobin S polymerization inhibitor and is used to treat sickle cell disease in people 4 years and older.

How does OXBRYTA ODT work?

How does OXBRYTA ODT work?

OXBRYTA ODT works by attaching to your hemoglobins. This prevents them from clumping up, which in turn, prevents your RBCs from sickling.

How do I take OXBRYTA ODT?

How do I take OXBRYTA ODT?

OXBRYTA ODT is available as 2 different tablet strengths, 300 mg and 500 mg. The 300 mg tablets for suspension are round shaped and are only to be used to make a suspension taken by mouth. The 500 mg tablets are oval shaped and must be swallowed whole.

  • Adults and children 12 years and older: The typical dose is 1,500 mg by mouth once per day

Children 4 to 11 years old: The typical dose is based on your child’s weight:

  • 88 lbs or more: 1,500 mg by mouth once per day
  • 44 to 88 lbs: 900 mg by mouth once per day
  • 22 to 44 lbs: 600 mg by mouth once per day

Your dose might differ if you have severe liver problems or if you’re taking medications that interact with Oxbryta (voxelotor).

Is it safe for me to take OXBRYTA ODT?

Is it safe for me to take OXBRYTA ODT?

OXBRYTA ODT is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

OXBRYTA ODT Common Side Effects

OXBRYTA ODT Common Side Effects

Common side effects of OXBRYTA ODT:

  • Vomiting
  • Headache
  • Diarrhea
  • Stomach pain
  • Nausea
  • Fever
  • Rash
OXBRYTA ODT Serious Side Effects

OXBRYTA ODT Serious Side Effects

Serious side effects are rare with OXBRYTA ODT. Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: rash, trouble breathing, swelling of lips, tongue, or face
Effects of other drugs, drug classes and over-the-counter products on OXBRYTA ODT

Effects of other drugs, drug classes and over-the-counter products on OXBRYTA ODT

The following medications may interact with OXBRYTA ODT:

  • Sensitive CYP3A4 Substrates: Avoid coadministration of sensitive
  • CYP3A4 substrates with a narrow therapeutic index.
  • Strong or moderate CYP3A4 Inducers: Avoid coadministration with strong or moderate CYP3A4 inducers. If unavoidable, increase the dose of OXBRYTA.
Who makes OXBRYTA ODT?

Who makes OXBRYTA ODT?


Is OXBRYTA ODT safe in pregnancy?

Is OXBRYTA ODT safe in pregnancy?

It is not known if OXBRYTA ODT harms your unborn baby. NYVEPRIA should be given to a pregnant woman only if clearly needed. Talk to your doctor about stopping OXBRYTA ODT if you are pregnant or planning to become pregnant.


What to do if you missed your OXBRYTA ODT dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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