View OTEZLA savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or OTEZLA Patient Assistance Program.

Programs are suitable for individuals who want to buy OTEZLA without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Amgen Inc.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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    Rx Advantage Card

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    Save up to 90%

  • Available

    Canadian Prescription Savings

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  • Available

    Drug Coupons

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    Pay as little as $0

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    Patient Assistance Programs

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about OTEZLA

What is OTEZLA?

What is OTEZLA?

OTEZLA is the brand name for apremilast oral tablets.

What dosages is OTEZLA available in?

What dosages is OTEZLA available in?

OTEZLA is available as a 10 mg, 20 mg, 30 mg oral tablet.

What is OTEZLA used for?

What is OTEZLA used for?

OTEZLA is a PDE-4 inhibitor and is used for the following:
Active psoriatic arthritis
Plaque psoriasis
Mouth sores from Behçet’s disease

How does OTEZLA work?

How does OTEZLA work?

OTEZLA is a phosphodiesterase-4 (PDE-4) inhibitor. It blocks a protein called PDE-4 that plays a role in causing inflammation in your body. This helps to lower inflammation.

How do I take OTEZLA?

How do I take OTEZLA?

OTEZLA is dosed as follows:
To lower your risk of stomach-related side effects, your provider will start you at a low dose and slowly raise it up over 5 days. The typical dosing schedule is outlined below.

Day 1: 10 mg by mouth in morning

Day 2: 10 mg in the morning and 10 mg in the evening

Day 3: 10 mg in the morning and 20 mg in the evening

Day 4: 20 mg in the morning and 20 mg in the evening

Day 5: 20 mg in the morning and 30 mg in the evening

Day 6 and beyond: 30 mg twice daily

Your dose might differ if you have kidney problems.

Is it safe for me to take OTEZLA?

Is it safe for me to take OTEZLA?

OTEZLA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

OTEZLA Common Side Effects

OTEZLA Common Side Effects

Common side effects of OTEZLA:

  • Diarrhea
  • Nausea
  • Upper respiratory tract infection
  • Headache
OTEZLA Serious Side Effects

OTEZLA Serious Side Effects

Serious side effects are rare with OTEZLA. Contact your healthcare provider immediately if you experience any of the following.

Suicidal thoughts or behavior
Severe allergic reaction: hives; trouble breathing; swelling of the lips, tongue, or throat

Effects of other drugs, drug classes and over-the-counter products on OTEZLA

Effects of other drugs, drug classes and over-the-counter products on OTEZLA

The following medications may interact with OTEZLA:

  • OTEZLA levels and effects can be decreased if it is co-administered with strong CYP450 inducers (such as rifampin).
Who makes OTEZLA?

Who makes OTEZLA?

Amgen Inc.

Is OTEZLA safe in pregnancy?

Is OTEZLA safe in pregnancy?

Based on findings from animal reproduction studies, OTEZLA may increase the risk for fetal loss. Notify your doctor if you become pregnant.
There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to OTEZLA during
pregnancy. Information about the registry can be obtained by calling 1-877-311-8972 or visiting


What to do if you missed your OTEZLA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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