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Ohtuvayre (ensifentrine) is an inhalation suspension used in COPD.

Ohtuvayre is available as a 3 mg/2.5 mL suspension in unit-dose ampules.

Ohtuvayre is a phosphodiesterase 3 (PDE3) inhibitor and phosphodiesterase 4 (PDE4) inhibitor used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults.

Ohtuvayre blocks two proteins in the body called PDE3 and PDE4. By blocking these proteins, the medicine helps relax the muscles around the airways in the lungs. This helps to reduce COPD symptoms such as coughing, wheezing, and shortness of breath.

Ohtuvayre is typically dosed as 3 mg (one ampule) twice daily given by oral inhalation using a standard jet nebulizer with a mouthpiece.

Ohtuvayre is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are allergic to ensifentrine or any inactive ingredients in the product.

Common side effects of Ohtuvayre: Back pain, Increased blood pressure, Urinary tract infections, Diarrhea

Serious side effects are rare with Ohtuvayre. Contact your healthcare provider immediately if you experience any of the following: Allergic reactions: skin rash, itching, hives, swelling of the face, lips, tongue, or throat Mood and behavior changes: anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression Wheezing or trouble breathing that is worse after use

There are no drug interactions listed for Ohtuvayre.

Verona Pharma plc

It is not known whether Ohtuvayre will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.

• Ensifentrine