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Novolog Mix 70/30 is the brand name for 70% insulin aspart protamine (intermediate-acting insulin) and 30% insulin aspart (rapid-acting insulin) that can be used as a subcutaneous injection.

Novolog Mix 70/30 is available as a vial and FlexPen that contains 100 units/ml.

Novolog Mix 70/30 is an insulin and is used for the following:

• Type 1 diabetes
• Type 2 diabetes

Novolog Mix 70/30 is a mixture of two insulins, 70% insulin aspart protamine (intermediate-acting insulin) and 30% insulin aspart (rapid-acting insulin). Insulin is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. A combination of an intermediate-acting and a rapid-acting insulin helps to meet your body’s insulin needs throughout the day as well as during meals.

Novolog Mix 70/30 is injected underneath the skin (subcutaneously) twice per day. The number of units of insulin is different for each person. It depends on if you are using it for type 1 diabetes or type 2 diabetes, your weight, how well you respond to insulin, and your blood sugar levels. Your healthcare provider will provide you with directions on how many units of insulin to inject, how to check your own blood sugar levels, and how to make any necessary adjustments in your insulin dose.

Novolog Mix 70/30 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of hypoglycemia.

Common side effects of Novolog Mix 70/30:

• Low blood sugar
• Headache
• Flu-like symptoms
• Weight gain
• Injection site reaction (skin irritation, itching, rash, skin thickening)

Serious side effects are rare with Novolog Mix 70/30. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood sugar (if not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death)
• Severe allergic reactions (rash, hives, swelling of face, tongue, and throat, difficulty breathing)
• Dangerously low levels of potassium (if not treated, it can lead to difficulty breathing, irregular heartbeat, and even death)

The following medications may interact with Novolog Mix 70/30:

• Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g. octreotide), and sulfonamide antibiotics
• Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics estrogens, glucagon, isoniazid, niacin, oral contraceptives phenothiazines, progestogens (e.g., in oral contraceptives) protease inhibitors, somatropin, sympathomimetic agents (e.g. albuterol, epinephrine, terbutaline), and thyroid hormones
• Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine
• Drugs that may blunt the signs and symptoms of hypoglycemia: beta-blockers, clonidine, guanethidine, and reserpine

Novo Nordisk Inc.

Published studies with Novolog Mix 70/30 used during pregnancy have not reported an association between its use and the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving Novolog Mix 70/30, talk to your healthcare provider.

• Insulin Aspart Protamine/Insulin Aspart Injectable Suspension