NOLVADEX
Used for Cancer
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Manufactured by AstraZeneca
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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NOLVADEX Uses, Side Effects, Interactions, Warnings & Dosing
What is NOLVADEX?
NOLVADEX is the brand name for tamoxifen and is available as an oral tablet.
What dosages is NOLVADEX available in?
NOLVADEX is available as a 10 mg and 20 mg oral tablet.
What is NOLVADEX used for?
NOLVADEX is a selective estrogen receptor modulator (SERM) that is used for:
- Metastatic HR+ breast cancer
- Early stage HR+ breast cancer after surgery to reduce the risk of breast cancer coming back
- Ductal carcinoma in situ (DCIS) in women after breast surgery and radiation to reduce the risk of breast cancer coming back
- Lowering the risk of getting breast cancer in women who are considered high risk
How does NOLVADEX work?
NOLVADEX is a selective estrogen receptor modulator (SERM). Some breast cancers rely on hormones like estrogen to grow. These breast cancers are called hormone receptor-positive (HR+). Tamoxifen works to treat HR+ breast cancer by blocking estrogen from working on breast tissue. By blocking estrogen, cancer cells don’t have the fuel they need to grow, which stops breast cancer from growing and spreading.
How do I take NOLVADEX?
NOLVADEX is typically taken as 20 to 40 mg by mouth once daily. You will usually take NOLVADEX for 5 to 10 years depending on the condition being treated.
Is it safe for me to take NOLVADEX?
NOLVADEX is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are pregnant or are taking a coumarin-type anticoagulant therapy or in women with a history of deep vein thrombosis or pulmonary embolus
NOLVADEX Common Side Effects
Common side effects of NOLVADEX:
- Hot flashes
- Vaginal discharge
- Swelling in the arms and legs
- Nausea
- Irregular or no monthly bleeding
- Vaginal bleeding
- Weight loss
- Skin changes
NOLVADEX Serious Side Effects
Serious side effects are rare with NOLVADEX. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots in your veins or lungs: pain or swelling in your arms or legs, trouble breathing, chest pain, fast heartbeat
- Stroke: severe headache, sudden confusion, weakness on one side of your body, or trouble speaking or walking
- Cancers of the uterus: abnormal vaginal bleeding or discharge, pain or pressure in the area below the belly button (pelvis)
Effects of other drugs, drug classes and over-the-counter products on NOLVADEX
The following medications may interact with NOLVADEX:
- When NOLVADEX is used in combination with cytotoxic agents, there is increased risk of thromboembolic events occurring
- Coumadin and other coumarin type anticoagulant use with NOVALDEX is contraindicated.
- Rifampicin use may cause a reduction in NOLVADEX plasma levels
- Reduced efficacy on NOLVADEX has been reported with concomitant usage of some SSRI antidepressants (e.g. paroxetine)
- For the primary reduction of breast cancer risk, there is some evidence that hormone replacement therapy may reduce the effectiveness of NOVALDEX
Who makes NOLVADEX?
AstraZeneca
Is NOLVADEX safe in pregnancy?
NOLVADEX should not be used if you are pregnant. Based on data from animal studies, NOLVADEX might cause harm to your unborn baby. If you’re a woman who’s able to have babies, you should use non-hormonal birth control, like condoms or a diaphragm, while taking NOLVADEX and for 2 months after the last dose.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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