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Motegrity is the brand name for prucalopride and is available as an oral tablet.

Motegrity is available as a 1 mg and 2 mg oral tablet.

Motegrity is a serotonin receptor agonist and is used to treat long-term constipation due to an unclear cause (idiopathic) in adults.

Motegrity is a serotonin receptor agonist. It targets the serotonin receptors (or proteins) in your colon that trigger natural contractions of your colon muscles (known as peristalsis). This helps push food through your digestive tract so that stool can pass more loosely and easily.

Motegrity is typically dosed as 2 mg by mouth once daily. If you have severe kidney problems, your dose may be adjusted to 1 mg by mouth once daily.

Motegrity is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Hypersensitivity to Motegrity
• Intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract such as Crohn’s disease, ulcerative colitis, and toxic megacolon/megarectum

Common side effects of Motegrity:

• Headache
• Abdominal pain
• Nausea
• Diarrhea

Serious side effects are rare with Motegrity. Contact your healthcare provider immediately if you experience any of the following.

• Suicidal thoughts and behavior

There are no major drug interactions listed for Motegrity. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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It is not known if Motegrity will harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Prucalopride