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MEDICAL INFORMATION
Mifepristone Key Facts
What dosages is Mifepristone available in?
Mifepristone is available as a 300 mg oral tablet.
What is Mifepristone used for?
Mifepristone is used to high blood sugar levels in adults with Cushing’s syndrome and Type 2 diabetes who can’t have surgery or who’ve already tried surgery.
How does Mifepristone work?
Mifepristone is a cortisol receptor blocker. It stops cortisol from attaching to its receptors to help lower blood sugar in people with Cushing’s syndrome.
How do I take Mifepristone?
The recommended starting dose of Mifepristone is 300 mg once daily. Based on your clinical response and tolerability, the dose may be increased in 300 mg increments to a maximum of 1200 mg once daily.
Is it safe for me to take Mifepristone?
Mifepristone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Allergy to Mifepristone
- Currently pregnant
- Unexplained vaginal bleeding
- Endometrial thickening
- Take oral or injected corticosteroids for life-saving conditions
- Take certain medications that interact with Mifepristone
Mifepristone Common Side Effects
Common side effects of Mifepristone:
- Nausea
- Fatigue
- Headache
- Low potassium levels
- Joint pain
- Vomiting
- Swelling in the hands, ankles, or feet
- High blood pressure
- Dizziness
- Low appetite
- Dry mouth
Mifepristone Serious Side Effects
Serious side effects are rare with Mifepristone. Contact your healthcare provider immediately if you experience any of the following:
- Serious allergic reaction: trouble breathing; hives; swelling of your face, lips, tongue, or throat
- Low potassium levels: irregular heart beat, fatigue, muscle weakness, high blood pressure
- Abnormal heart rhythm (QT prolongation): chest pounding, chest pain, shortness of breath, feeling faint or lightheaded
Effects of other drugs, drug classes and over-the-counter products on Mifepristone
The following medications may interact with Mifepristone:
- Drugs metabolized by CYP3A
- CYP3A inhibitors and inducers
- Drugs metabolized by CYP2C8/2C9 and CYP2B6
- Hormonal contraceptives
Who makes Mifepristone?
Various FDA-approved generic manufacturers
Is Mifepristone safe in pregnancy?
Mifepristone can cause a loss of pregnancy. Women who can become pregnant must:
- Have a negative pregnancy test before starting Mifepristone
- Have a negative pregnancy test before restarting Mifepristone if you stop taking it for more than 14 days
- Use a non-hormonal form of birth control while on this medication and for 1 month after stopping it
- Tell your doctor immediately if you think you may be pregnant
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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