Used for Hypertension

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Manufactured by various FDA-approved generic manufacturers.

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metyrosine Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is metyrosine available in?

What dosages is metyrosine available in?

metyrosine is available as a 250 mg oral capsule.

What is metyrosine used for?

What is metyrosine used for?

metyrosine is a tyrosine hydroxylase inhibitor and is used for the following:

  • Treatment of pheochromocytoma for:
  • Preparation for surgery to remove the tumors
  • People who aren’t able to have surgery
  • Long-term treatment of people with malignant pheochromocytoma (cancer)
How does metyrosine work?

How does metyrosine work?

metyrosine is a tyrosine hydroxylase inhibitor, meaning it blocks a protein in the body called tyrosine hydroxylase. This protein is responsible for making hormones called catecholamines. People who have pheochromocytoma have tumors that make too many of these catecholamines. So metyrosine works by lowering the amount of catecholamines that are made. This can reduce the symptoms like high blood pressure, headaches, sweating, and a fast heart beat.

How do I take metyrosine?

How do I take metyrosine?

metyrosine is dosed as follows:

  • Adults and children 12 years and older: The typical starting dose is 250 mg by mouth 4 times a day. Your provider will adjust your dose based on your response to the medication. The maximum dose is 4 grams per day
  • How long you take metyrosine depends on what you’re using the medication for
Is it safe for me to take metyrosine?

Is it safe for me to take metyrosine?

metyrosine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

metyrosine Common Side Effects

metyrosine Common Side Effects

Common side effects of metyrosine:

  • Drowsiness
  • Drooling
  • Difficulty speaking
  • Shakiness
  • Diarrhea
metyrosine Serious Side Effects

metyrosine Serious Side Effects

Serious side effects are rare with metyrosine. Contact your healthcare provider immediately if you experience any of the following.

  • Mental health changes: depression, hallucinations (seeing things that aren’t there), confusion
  • Extrapyramidal symptoms (EPS): drooling, trouble speaking, tremor, muscle spasms, tightness in your jaw
  • Low blood cell counts: feeling tired, paleness, blood in urine or stool, unexplained bruising
  • Severe allergic reaction: hives, swelling in the throat, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on metyrosine

Effects of other drugs, drug classes and over-the-counter products on metyrosine

The following medications may interact with metyrosine:

  • Caution should be observed in administering metyrosine to patients receiving phenothiazines or haloperidol because the extrapyramidal effects of these drugs can be expected to be potentiated by inhibition of catecholamine synthesis
  • Concurrent use of metyrosine with alcohol or other CNS depressants can increase their sedative effects
Who makes metyrosine?

Who makes metyrosine?

Various FDA-approved generic manufacturers

Is metyrosine safe in pregnancy?

Is metyrosine safe in pregnancy?

It is not known if metyrosine will harm your unborn baby. Talk with your healthcare provider if you are pregnant or plan to become pregnant.


What to do if you missed your metyrosine dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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