LYNPARZA
Used for Cancer
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Manufactured by AstraZeneca
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LYNPARZA Uses, Side Effects, Interactions, Warnings & Dosing
What is LYNPARZA?
LYNPARZA is the brand name for olaparib and is available as an oral tablet.
What dosages is LYNPARZA available in?
LYNPARZA is available as a 100 mg and 150 mg oral tablet.
What is LYNPARZA used for?
LYNPARZA is a PARP inhibitor that is used to treat:
- Advanced or recurrent ovarian cancer after treatment with platinum-based chemotherapy
- HER2-negative early or metastatic breast cancer with inherited BRCA mutations, typically after initial treatment
- Pancreatic cancer with inherited BRCA mutations, after treatment with first-choice platinum-based chemotherapy
- Metastatic, castration-resistant prostate cancer with BRCA or HRR gene mutations
How does LYNPARZA work?
LYNPARZA is a PARP inhibitor, which means it stops the PARP protein in the body from working. The PARP protein normally helps cells, including cancer cells, grow and survive by fixing damaged DNA. By blocking PARP from working, it prevents cancer cells from repairing their DNA, which kills them.
How do I take LYNPARZA?
The typical dose of LYNPARZA is 300 mg by mouth twice a day, with or without food.
- Your dose might differ if you have kidney problems, take other medications that interact with LYNPARZA, or experience side effects from LYNPARZA
- Ovarian cancer: If Avastin (bevacizumab) was part of your previous treatment plan, it’s likely you’ll continue Avastin while taking LYNPARZA
- Prostate cancer: While you’re taking LYNPARZA, you’ll need to continue testosterone-lowering treatments, such as leuprolide (Lupron) or have had testicles removed (orchiectomy)
Is it safe for me to take LYNPARZA?
LYNPARZA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
LYNPARZA Common Side Effects
Common side effects of LYNPARZA:
- Lower blood cell counts
- Nausea
- Fatigue
- Stomach pain
- Vomiting
- Diarrhea
- Signs of kidney stress
LYNPARZA Serious Side Effects
Serious side effects are rare with LYNPARZA. Contact your healthcare provider immediately if you experience any of the following.
- Bone marrow problems or new cancers: feeling very weak or tired, bruising or bleeding easily, blood in the urine or stool, fevers, unexplained weight loss
- Lung problems: having trouble catching your breath, fever, cough, wheezing
- Blood clots: pain or swelling in the arms or legs, having trouble catching your breath, chest pain, weakness, trouble speaking
Effects of other drugs, drug classes and over-the-counter products on LYNPARZA
The following medications may interact with LYNPARZA:
- Strong or moderate CYP3A inhibitors: Avoid concomitant use
- If concomitant use cannot be avoided, reduce Lynparza dosage
- Strong or moderate CYP3A inducers: Avoid concomitant use
Who makes LYNPARZA?
AstraZeneca
Is LYNPARZA safe in pregnancy?
LYNPARZA can harm your unborn baby and may cause loss of
pregnancy (miscarriage). If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with LYNPARZA. Females who are able to become pregnant should use effective birth control (contraception) during treatment with LYNPARZA and
for 6 months after the last dose of LYNPARZA. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you might be pregnant following treatment with LYNPARZA. Males with female partners who are pregnant or able to become pregnant should use effective birth control (contraception) during treatment with Lynparza and for 3 months after the last dose of LYNPARZA. Do not donate sperm during treatment with LYNPARZA and for 3 months after your last dose.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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