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Lubiprostone is available as an 8 mcg and 24 mcg capsule.

Lubiprostone is a chloride channel activator and is used for the following:

• Long-term constipation due to unclear cause (idiopathic)
• Constipation due to opioids
• Constipation due to irritiable bowel syndrome (IBS) in women 18 years or older

Lubiprostone is a chloride channel activator. It raises the amount of chloride and fluid in the intestines, so that stool can pass more loosely and easily.

Lubiprostone is dosed as follows:

• Constipation due to opioids or unclear cause: Take 24 mcg by mouth twice daily
• Constipation due to irritable bowel syndrome: Women who are age 18 years or older should take 8 mcg by mouth twice daily

Lubiprostone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known or suspected mechanical gastrointestinal
obstruction.

Common side effects of Lubiprostone:

• Nausea
• Diarrhea

Serious side effects are rare with Lubiprostone. Contact your healthcare provider immediately if you experience any of the following.

• Severe diarrhea
• Low blood pressure or fainting
• Difficulty breathing

No drug–drug interaction studies have been performed with Lubiprostone. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

There are no adequate and well-controlled studies with Lubiprostone in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Amitiza