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Linagliptin is available as a 5 mg oral tablet.

• Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes in adults

Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by blocking DPP-4, a protein that breaks down certain hormones in your body. These hormones normally tell your body to make more insulin and produce less sugar. When DPP-4 causes these hormone levels to drop, you end up having high blood sugar levels. By blocking the action of DPP-4, Linagliptin helps your body produce more insulin and make less sugar. In doing so, Linagliptin helps lower your blood sugar levels.

• Linagliptin is typically dosed as 5 mg by mouth once daily

Linagliptin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Linagliptin:

• Common cold (runny nose, sneezing, coughing)
• Diarrhea
• Cough
• Urinary tract infection symptoms (e.g., pain while urinating, frequent urination)
• Weight gain

Serious side effects are rare with Linagliptin. Contact your healthcare provider immediately if you experience any of the following.

• Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
• Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling

The following medications may interact with Linagliptin:

• Strong P-glycoprotein/CYP3A4 inducer: The efficacy of Linagliptin may be reduced when administered in combination (e.g., with rifampin). Use of alternative treatments is strongly recommended

Various FDA-approved generic manufacturers

It is not known if Linagliptin will harm your unborn baby. If you become pregnant while receiving Linagliptin talk to your healthcare provider.

• Tradjenta