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Leuprolide is available as follows:

• For 1-month administration: 7.5 mg, 11.25 mg, or 15 mg
• For 3-month administration: 11.25 mg or 30 mg
• For 6-month administration: 45 mg

Leuprolide is a GnRH agonist and is used to treat advanced prostate cancer.

Leuprolide is a gonadotropin-releasing hormone (GnRH) agonist, which is a synthetic (lab-made) hormone similar to the GnRH your body naturally makes. Over time, it lowers testosterone levels, which helps slow down the growth of the prostate gland and cancer cells.

Leuprolide is typically dosed as follows:

• Leuprolide Depot: The typical dosing range is 7.5 mg to 45 mg injected into your muscle by a healthcare provider. Depending on the dose, the medication is injected every month, every 3 months, every 4 months, or every 6 months. It’s either injected in your shoulder, buttock, or outer thigh muscle
• Eligard: The typical dosing range is 7.5 mg to 45 mg injected under the skin by a healthcare provider. Depending on the dose, the medication is injected every month, every 3 months, every 4 months, or every 6 months. It’s usually injected under the skin in your stomach or upper buttock area
• Camcevi: The typical dose is 42 mg injected under the skin every 6 months by a healthcare provider. It’s injected under the skin in your stomach

Leuprolide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Hypersensitivity reactions to GnRH, GnRH agonists or any of the excipients in LUPRO
• Pregnancy

Common side effects of Leuprolide:

• Hot flashes or sweats
• Injection site reaction (e.g., burning, stinging)
• Pain (e.g., general, muscle, bone, joint)
• Tiredness
• Swelling
• Breathing problems
• Digestive system problems
• Urinary problems
• Shrinking of testicles
• High blood pressure

Serious side effects are rare with Leuprolide. Contact your healthcare provider immediately if you experience any of the following.

• Heart problems: racing heart, fluttering in your chest, abnormal heartbeats, heart attack, stroke
• Convulsions (seizures): tight muscles, uncontrollable movements, painful cramping

No pharmacokinetic-based drug-drug interaction studies have been conducted with Leuprolide. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Leuprolide is contraindicated in pregnancy as it can cause birth defects or loss of the baby.

• Lupron