LetrozolePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Letrozole
    Generic for Femara
    30 tablets $5.7 USD
    Save $210.30
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Do you need a prescription for letrozole?

Yes, letrozole is only available with a valid physician Rx.

How much is letrozole without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase letrozole, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for letrozole in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a letrozole savings card?

Yes. Save up to 90% on your letrozole with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a letrozole coupon provider in the US?

No. Now Patient does not provide letrozole coupons or FREE letrozole samples.

Do you accept commercial, Medicare or Medicaid coverage for letrozole in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much letrozole?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using letrozole. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much letrozole. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic letrozole?

Generic letrozole refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of letrozole

Letrozole is approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain types of breast cancer in postmenopausal women.

Active ingredient of letrozole

The active ingredient of letrozole is letrozole.

US brand name of letrozole and manufacturer

Letrozole is available in the US under the brand name Femara. The manufacturer is Novartis Pharmaceuticals Corporation.

UK brand name of letrozole and manufacturer

In the UK, letrozole is available under the brand name Femara. The manufacturer is also Novartis Pharmaceuticals Corporation.

Prescription requirement for letrozole

A prescription (Rx) is required for letrozole in both the US and the UK.

Availability of letrozole in the UK with NHS prescription

Letrozole is available in the UK with an NHS prescription.

Conditions treated by letrozole

Letrozole is primarily used for the treatment of hormone receptor-positive breast cancer in postmenopausal women (women that have been through menopause). It may be prescribed as part of adjuvant therapy or for advanced/metastatic breast cancer.

How does letrozole work?

Letrozole belongs to a class of medications called aromatase inhibitors. It works by reducing the production of estrogen in the body. Estrogen can promote the growth of hormone receptor-positive breast cancer cells. By lowering estrogen levels, letrozole helps to inhibit the growth of cancer cells.

Forms of letrozole available

Letrozole is available in oral tablet form.

Dosage of letrozole

The dosage of letrozole may vary depending on the specific condition being treated and individual patient factors. It is important to follow the recommended dosage instructions provided by the healthcare provider.

If you forget to take your medication, take it as soon as you remember. Skip the missed dose if it’s almost time for your next dose.

Directions for letrozole use

Letrozole should be taken as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions.

Is letrozole safe to take if I am breastfeeding?

It is not recommended to take letrozole while breastfeeding. Letrozole may pass into breast milk and potentially harm the nursing infant. It is important to discuss the potential risks and benefits with a healthcare provider before using letrozole while breastfeeding.

Is it safe to take letrozole if I am pregnant or planning on becoming pregnant?

Letrozole is contraindicated for use during pregnancy. It may cause harm to the developing fetus. Use birth control or an effective form of contraception to prevent pregnancy during treatment. If you are planning to become pregnant or suspect that you are pregnant, it is important to inform your healthcare provider. They can provide guidance and recommend alternative treatment options.

Warnings and precautions for letrozole

  • Letrozole may cause bone loss or osteoporosis, especially in postmenopausal women. Regular bone density monitoring may be recommended during treatment
  • Your doctor will also monitor your blood pressure and cholesterol levels as these can also be affected when taking letrozole
  • It is important to inform the healthcare provider about any existing medical conditions, allergies, and any other medications or supplements you are currently taking, to avoid potential drug interactions

Interactions with other drugs

Letrozole tablets may interact with certain medications, including hormonal therapies, tamoxifen, and estrogen-containing products. It is important to inform the healthcare provider about all medications and supplements you are taking to minimize the risk of interactions.

Possible side effects of letrozole

Common side effects of letrozole may include constipation, diarrhea, hot flashes, joint pain, bone pain, and muscle pain, tiredness, headache, blurred vision and increased sweating. Rarely, it’s possible to have a severe allergic reaction to letrozole. If these serious side effects persist or worsen, it is important to contact a healthcare provider.

Similar drugs to letrozole

Other aromatase inhibitors, such as anastrozole and exemestane, may be used as alternatives to letrozole for the treatment of hormone receptor-positive breast cancer in postmenopausal women.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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