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Izervay is the brand name for avacincaptad pegol and is available as an injection given into the eye.

Izervay is available as a 20 mg/mL in a single-dose vial.

Izervay is used to treat adults with geographic atrophy (GA), an advanced form of age-related macular degeneration (AMD).

Izervay is a complement inhibitor that blocks complement protein C5. C5 is a protein in your immune system that plays a role in GA (inflammation and cell death in the retina and eventual vision loss). Blocking it reduces inflammation and helps protect your retina from further damage and possibly lowers your risk of vision loss.

The recommended dose for Izervay is 2 mg (0.1 mL of 20 mg/mL solution) injected into each affected eye once monthly.

Izervay is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Current infection in or around the eye
• Current eye inflammation

Common side effects of Izervay:

• Blood spots on the whites of eye or eye redness
• Increased eye pressure
• Blurry vision

Serious side effects are rare with Izervay. Contact your healthcare provider immediately if you experience any of the following:

• Eye infection: eye pain, sensitivity to light, loss of vision, eye redness
• Retinal detachment: flashing lights, feeling like something is covering your vision, changes in your vision, vision loss, seeing floaters
• Signs of wet AMD: straight lines looking wavy, blurry vision, blank spots in your vision

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Astellas Pharma

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Avacincaptad Pegol Intravitreal Solution